AIM: To determine whether the SNP rs4149056 in SLCO1B1 alters the pharmacodynamics of pravastatin. METHODS: rs4149056 was genotyped in 626 pravastatin-treated participants in the WOSCOPS trial and the response after 1 year of treatment was compared between the different genotypes. RESULTS: Pravastatin reduced serum LDL cholesterol by 22.2% in TT homozygotes, by 22.2% in TC heterozygotes and by 17.7% in CC homozygotes (TT + TC vs. CC P value 0.33). There were no significant differences in the response of total cholesterol, LDL, HDL, triglycerides or CRP to pravastatin between the genotypes. CONCLUSION: The rs4149056 SNP did not significantly affect the pharmacodynamics of pravastatin.
AIM: To determine whether the SNP rs4149056 in SLCO1B1 alters the pharmacodynamics of pravastatin. METHODS:rs4149056 was genotyped in 626 pravastatin-treated participants in the WOSCOPS trial and the response after 1 year of treatment was compared between the different genotypes. RESULTS:Pravastatin reduced serum LDL cholesterol by 22.2% in TT homozygotes, by 22.2% in TC heterozygotes and by 17.7% in CC homozygotes (TT + TC vs. CC P value 0.33). There were no significant differences in the response of total cholesterol, LDL, HDL, triglycerides or CRP to pravastatin between the genotypes. CONCLUSION: The rs4149056 SNP did not significantly affect the pharmacodynamics of pravastatin.
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