OBJECTIVE: To evaluate the applicability of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) in Chinese patients of different stages of CKD. METHODS: The CKD-EPI equation estimated GFR (eGFR) was compared with body surface area standardized GFR (sGFR), which was measured by diethylenetriaminepentaacetic acid renal dynamic imaging method in 142 CKD cases. RESULTS: eGFR was positively correlated with sGFR (r = 0.838, p < 0.001). eGFR of 15%, 30%, and 50% accuracy were 31.0%, 57.7%, and 76.8%, respectively. Average deviation of eGFR from sGFR was -0.92 ± 16.36 mL/min/1.73 m2 (p = 0.506). There was no significant deviation in the CKD from stages 2 to 5. However, in CKD stage 1, the deviation was increased with the value of 13.36 ± 18.44 mL/min/1.73 m(2) (p = 0.023). CONCLUSION: CKD-EPI equation might be widely used in evaluation of Chinese CKD patients of different stages, with a less deviation and higher accuracy. However, in CKD stage 1, eGFR was higher than sGFR on average. It was suggested that eGFR might be overcorrected or overestimated. These results demonstrated that careful modification of CKD-EPI equation would be necessary in Chinese populations with CKD.
OBJECTIVE: To evaluate the applicability of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) in Chinese patients of different stages of CKD. METHODS: The CKD-EPI equation estimated GFR (eGFR) was compared with body surface area standardized GFR (sGFR), which was measured by diethylenetriaminepentaacetic acid renal dynamic imaging method in 142 CKD cases. RESULTS: eGFR was positively correlated with sGFR (r = 0.838, p < 0.001). eGFR of 15%, 30%, and 50% accuracy were 31.0%, 57.7%, and 76.8%, respectively. Average deviation of eGFR from sGFR was -0.92 ± 16.36 mL/min/1.73 m2 (p = 0.506). There was no significant deviation in the CKD from stages 2 to 5. However, in CKD stage 1, the deviation was increased with the value of 13.36 ± 18.44 mL/min/1.73 m(2) (p = 0.023). CONCLUSION: CKD-EPI equation might be widely used in evaluation of Chinese CKD patients of different stages, with a less deviation and higher accuracy. However, in CKD stage 1, eGFR was higher than sGFR on average. It was suggested that eGFR might be overcorrected or overestimated. These results demonstrated that careful modification of CKD-EPI equation would be necessary in Chinese populations with CKD.
Authors: Sangmi Lee; Myeongkyun Kang; Keunho Byeon; Sang Eun Lee; In Ho Lee; Young Ah Kim; Shin-Wook Kang; Jung Tak Park Journal: J Digit Imaging Date: 2022-04-11 Impact factor: 4.903
Authors: Ajay K Singh; Youssef M K Farag; Bharati V Mittal; Kuyilan Karai Subramanian; Sai Ram Keithi Reddy; Vidya N Acharya; Alan F Almeida; Anil Channakeshavamurthy; H Sudarshan Ballal; Gaccione P; Rajan Issacs; Sanjiv Jasuja; Ashok L Kirpalani; Vijay Kher; Gopesh K Modi; Georgy Nainan; Jai Prakash; Devinder Singh Rana; Rajanna Sreedhara; Dilip Kumar Sinha; Shah Bharat V; Sham Sunder; Raj K Sharma; Sridevi Seetharam; Tatapudi Ravi Raju; Mohan M Rajapurkar Journal: BMC Nephrol Date: 2013-05-28 Impact factor: 2.388
Authors: Chi Pang Wen; Kunihiro Matsushita; Josef Coresh; Kunitoshi Iseki; Muhammad Islam; Ronit Katz; William McClellan; Carmen A Peralta; HaiYan Wang; Dick de Zeeuw; Brad C Astor; Ron T Gansevoort; Andrew S Levey; Adeera Levin Journal: Kidney Int Date: 2014-02-12 Impact factor: 10.612