Effect of diabetes and time after in vivo insulin administration on ketogenesis and gluconeogenesis in isolated rat hepatocytes.

1. Diabetic rats had elevated rates of gluconeogenesis and ketone body production. 2. Four hours after insulin administration the rate of gluconeogenesis returned to normal and the rate of ketogenesis decreased with certain substrates, but did not return to normal. 3. Eight hours after insulin treatment ketogenesis from all substrates was significantly reduced, but still significantly higher than normal.