BACKGROUND: Adults with moyamoya disease (MMD) have been shown to manifest cognitive impairment, but it is unclear whether this is the result of ischemic stroke. OBJECTIVE: To determine whether adults with MMD but without stroke have cognitive impairment. METHODS: We performed detailed neuropsychological assessments in 30 adults with angiographically confirmed MMD without magnetic resonance imaging (MRI) evidence of stroke. RESULTS: Twenty patients (67%) exhibited small T2 hyperintensities in the cerebral subcortical white matter on brain MRI but no evidence of gray matter damage. Significant cognitive impairment, defined as half of test scores ≥ 1 SD below the normal mean, was present in 7 patients (23%). Executive functioning, mental efficiency, and word finding were the ability areas most frequently impaired, whereas memory was relatively intact. Clinically significant emotional distress (depression and/or anxiety) was present in 11 patients (37%). Comparable cognitive findings were also observed in the subset of 10 patients (33%) with completely normal static brain MRI. CONCLUSION: Cognitive impairment in MMD can occur in the absence of ischemic stroke as manifested on MRI.
BACKGROUND: Adults with moyamoya disease (MMD) have been shown to manifest cognitive impairment, but it is unclear whether this is the result of ischemic stroke. OBJECTIVE: To determine whether adults with MMD but without stroke have cognitive impairment. METHODS: We performed detailed neuropsychological assessments in 30 adults with angiographically confirmed MMD without magnetic resonance imaging (MRI) evidence of stroke. RESULTS: Twenty patients (67%) exhibited small T2 hyperintensities in the cerebral subcortical white matter on brain MRI but no evidence of gray matter damage. Significant cognitive impairment, defined as half of test scores ≥ 1 SD below the normal mean, was present in 7 patients (23%). Executive functioning, mental efficiency, and word finding were the ability areas most frequently impaired, whereas memory was relatively intact. Clinically significant emotional distress (depression and/or anxiety) was present in 11 patients (37%). Comparable cognitive findings were also observed in the subset of 10 patients (33%) with completely normal static brain MRI. CONCLUSION:Cognitive impairment in MMD can occur in the absence of ischemic stroke as manifested on MRI.
Authors: Anna Scalise; Maria Elena Laino; Benedetto Petralia; Antonella Piani; Gian Luigi Gigli Journal: Neurol Sci Date: 2017-07-20 Impact factor: 3.307
Authors: K Kazumata; K K Tha; H Narita; Y M Ito; H Shichinohe; M Ito; H Uchino; T Abumiya Journal: AJNR Am J Neuroradiol Date: 2016-03-24 Impact factor: 3.825
Authors: Annick Kronenburg; Kees P J Braun; Albert van der Zwan; Catharina J M Klijn Journal: Curr Neurol Neurosci Rep Date: 2014-01 Impact factor: 5.081