Literature DB >> 21849463

A cluster of basic amino acids in the factor X serine protease mediates surface attachment of adenovirus/FX complexes.

Margaret R Duffy1, Angela C Bradshaw, Alan L Parker, John H McVey, Andrew H Baker.   

Abstract

Hepatocyte transduction following intravenous administration of adenovirus 5 (Ad5) is mediated by interaction between coagulation factor X (FX) and the hexon. The FX serine protease (SP) domain tethers the Ad5/FX complex to hepatocytes through binding heparan sulfate proteoglycans (HSPGs). Here, we identify the critical HSPG-interacting residues of FX. We generated an FX mutant by modifying seven residues in the SP domain. Surface plasmon resonance demonstrated that mutations did not affect binding to Ad5. FX-mediated, HSPG-associated cell binding and transduction were abolished. A cluster of basic amino acids in the SP domain therefore mediates surface interaction of the Ad/FX complex.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21849463      PMCID： PMC3187485          DOI： 10.1128/JVI.05382-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  14 in total

1.  Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding.

Authors:  A R Rezaie
Journal:  J Biol Chem       Date:  2000-02-04       Impact factor: 5.157

2.  Intermolecular interactions and characterization of the novel factor Xa exosite involved in macromolecular recognition and inhibition: crystal structure of human Gla-domainless factor Xa complexed with the anticoagulant protein NAPc2 from the hematophagous nematode Ancylostoma caninum.

Authors:  M T Murakami; J Rios-Steiner; S E Weaver; A Tulinsky; J H Geiger; R K Arni
Journal:  J Mol Biol       Date:  2006-11-14       Impact factor: 5.469

3.  Ixolaris: a factor Xa heparin-binding exosite inhibitor.

Authors:  Robson Q Monteiro; Alireza R Rezaie; José M C Ribeiro; Ivo M B Francischetti
Journal:  Biochem J       Date:  2005-05-01       Impact factor: 3.857

4.  Enhanced gamma-carboxylation of recombinant factor X using a chimeric construct containing the prothrombin propeptide.

Authors:  R M Camire; P J Larson; D W Stafford; K A High
Journal:  Biochemistry       Date:  2000-11-21       Impact factor: 3.162

5.  The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells.

Authors:  M Kim; K R Zinn; B G Barnett; L A Sumerel; V Krasnykh; D T Curiel; J T Douglas
Journal:  Eur J Cancer       Date:  2002-09       Impact factor: 9.162

6.  Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X.

Authors:  Angela C Bradshaw; Alan L Parker; Margaret R Duffy; Lynda Coughlan; Nico van Rooijen; Veli-Matti Kähäri; Stuart A Nicklin; Andrew H Baker
Journal:  PLoS Pathog       Date:  2010-10-07       Impact factor: 6.823

7.  Structure of human des(1-45) factor Xa at 2.2 A resolution.

Authors:  K Padmanabhan; K P Padmanabhan; A Tulinsky; C H Park; W Bode; R Huber; D T Blankenship; A D Cardin; W Kisiel
Journal:  J Mol Biol       Date:  1993-08-05       Impact factor: 5.469

8.  Adenovirus serotype 5 hexon mediates liver gene transfer.

Authors:  Simon N Waddington; John H McVey; David Bhella; Alan L Parker; Kristeen Barker; Hideko Atoda; Rebecca Pink; Suzanne M K Buckley; Jenny A Greig; Laura Denby; Jerome Custers; Takashi Morita; Ivo M B Francischetti; Robson Q Monteiro; Dan H Barouch; Nico van Rooijen; Claudio Napoli; Menzo J E Havenga; Stuart A Nicklin; Andrew H Baker
Journal:  Cell       Date:  2008-02-08       Impact factor: 41.582

9.  Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes.

Authors:  Alan L Parker; Simon N Waddington; Campbell G Nicol; Dmitry M Shayakhmetov; Suzanne M Buckley; Laura Denby; Geoffrey Kemball-Cook; Shaoheng Ni; Andre Lieber; John H McVey; Stuart A Nicklin; Andrew H Baker
Journal:  Blood       Date:  2006-06-20       Impact factor: 22.113

10.  Surface plasmon resonance studies of the interaction between factor VII and tissue factor. Demonstration of defective tissue factor binding in a variant FVII molecule (FVII-R79Q).

Authors:  D P O'Brien; G Kemball-Cook; A M Hutchinson; D M Martin; D J Johnson; P G Byfield; O Takamiya; E G Tuddenham; J H McVey
Journal:  Biochemistry       Date:  1994-11-29       Impact factor: 3.162
View more
  19 in total

1.  Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks.

Authors:  Camille Saini; André Liani; Thomas Curie; Pascal Gos; Florian Kreppel; Yann Emmenegger; Luigi Bonacina; Jean-Pierre Wolf; Yves-Alain Poget; Paul Franken; Ueli Schibler
Journal:  Genes Dev       Date:  2013-07-01       Impact factor: 11.361

2.  FX and host defense evasion tactics by adenovirus.

Authors:  Andrew H Baker; Stuart A Nicklin; Dmitry M Shayakhmetov
Journal:  Mol Ther       Date:  2013-06       Impact factor: 11.454

3.  Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting.

Authors:  Franziska Jönsson; Claudia Hagedorn; Florian Kreppel
Journal:  J Vis Exp       Date:  2018-10-26       Impact factor: 1.355

4.  Coagulation factor binding orientation and dimerization may influence infectivity of adenovirus-coagulation factor complexes.

Authors:  Eric E Irons; Justin W Flatt; Konstantin Doronin; Tara L Fox; Mauro Acchione; Phoebe L Stewart; Dmitry M Shayakhmetov
Journal:  J Virol       Date:  2013-06-26       Impact factor: 5.103

5.  Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice.

Authors:  Michelle B Trevino; David Mazur-Hart; Yui Machida; Timothy King; Joseph Nadler; Elena V Galkina; Arjun Poddar; Sucharita Dutta; Yumi Imai
Journal:  Mol Endocrinol       Date:  2015-08-21

Review 6.  Barriers to systemic application of virus-based vectors in gene therapy: lessons from adenovirus type 5.

Authors:  Franziska Jönsson; Florian Kreppel
Journal:  Virus Genes       Date:  2017-07-28       Impact factor: 2.332

7.  Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo.

Authors:  Anne K Zaiss; Erin M Foley; Roger Lawrence; Lina S Schneider; Hamidreza Hoveida; Patrick Secrest; Arthur B Catapang; Yu Yamaguchi; Ramon Alemany; Dmitry M Shayakhmetov; Jeffrey D Esko; Harvey R Herschman
Journal:  J Virol       Date:  2015-10-21       Impact factor: 5.103

8.  Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement.

Authors:  Zhili Xu; Qi Qiu; Jie Tian; Jeffrey S Smith; Gina M Conenello; Takashi Morita; Andrew P Byrnes
Journal:  Nat Med       Date:  2013-03-24       Impact factor: 53.440

9.  Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses.

Authors:  Angela C Bradshaw; Lynda Coughlan; Ashley M Miller; Raul Alba; Nico van Rooijen; Stuart A Nicklin; Andrew H Baker
Journal:  J Control Release       Date:  2012-05-22       Impact factor: 9.776

10.  Interaction between mouse adenovirus type 1 and cell surface heparan sulfate proteoglycans.

Authors:  Liesbeth Lenaerts; Wim van Dam; Leentje Persoons; Lieve Naesens
Journal:  PLoS One       Date:  2012-02-07       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.