Literature DB >> 21849430

Distal leucines are key functional determinants of Alix-binding simian immunodeficiency virus SIV(smE543) and SIV(mac239) type 3 L domains.

Nana F Bello1, Fan Wu, Paola Sette, Vincent Dussupt, Vanessa M Hirsch, Fadila Bouamr.   

Abstract

In addition to PTAP L domains, primate lentiviruses carry Alix-binding motifs that include the recently described type 3 SREKPYKEVTEDLLHLNSLF sequence. We examined the requirements for the type 3 sequence motif in simian immunodeficiency virus SIV(smE543) and identified the (499)LNSLF(503) sequence as a key functional determinant. Mutation of distal leucines (499)L and (502)L (LL mutant) caused an inhibitory effect on Alix-dependent SIV(smE543) release that was quantitatively similar to that observed following disruption of the type 3 L domain or RNA interference (RNAi) depletion of Alix. Similar results were obtained with the SIV(mac239) LL mutant. Thus, distal leucines are key determinants of SIV(smE543) and SIV(mac239) type 3 L domains.

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Year:  2011        PMID： 21849430      PMCID： PMC3194945          DOI： 10.1128/JVI.05284-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding.

Authors:  J E Garrus; U K von Schwedler; O W Pornillos; S G Morham; K H Zavitz; H E Wang; D A Wettstein; K M Stray; M Côté; R L Rich; D G Myszka; W I Sundquist
Journal:  Cell       Date:  2001-10-05       Impact factor: 41.582

2.  Structure and functional interactions of the Tsg101 UEV domain.

Authors:  Owen Pornillos; Steven L Alam; Rebecca L Rich; David G Myszka; Darrell R Davis; Wesley I Sundquist
Journal:  EMBO J       Date:  2002-05-15       Impact factor: 11.598

Review 3.  Mechanisms of enveloped RNA virus budding.

Authors:  Owen Pornillos; Jennifer E Garrus; Wesley I Sundquist
Journal:  Trends Cell Biol       Date:  2002-12       Impact factor: 20.808

4.  AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.

Authors:  Bettina Strack; Arianna Calistri; Stewart Craig; Elena Popova; Heinrich G Göttlinger
Journal:  Cell       Date:  2003-09-19       Impact factor: 41.582

5.  Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag).

Authors:  L VerPlank; F Bouamr; T J LaGrassa; B Agresta; A Kikonyogo; J Leis; C A Carter
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-26       Impact factor: 11.205

6.  Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.

Authors:  Juan Martin-Serrano; Anton Yarovoy; David Perez-Caballero; Paul D Bieniasz; Anton Yaravoy
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-30       Impact factor: 11.205

7.  The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release.

Authors:  Eva Gottwein; Jochen Bodem; Barbara Müller; Ariane Schmechel; Hanswalter Zentgraf; Hans-Georg Kräusslich
Journal:  J Virol       Date:  2003-09       Impact factor: 5.103

8.  The protein network of HIV budding.

Authors:  Uta K von Schwedler; Melissa Stuchell; Barbara Müller; Diane M Ward; Hyo-Young Chung; Eiji Morita; Hubert E Wang; Thaylon Davis; Gong-Ping He; Daniel M Cimbora; Anna Scott; Hans-Georg Kräusslich; Jerry Kaplan; Scott G Morham; Wesley I Sundquist
Journal:  Cell       Date:  2003-09-19       Impact factor: 41.582

9.  PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101 [corrected].

Authors:  Fadila Bouamr; Jessica A Melillo; Margaret Q Wang; Kunio Nagashima; Martha de Los Santos; Alan Rein; Stephen P Goff
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

10.  HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein.

Authors:  Owen Pornillos; Daniel S Higginson; Kirsten M Stray; Robert D Fisher; Jennifer E Garrus; Marielle Payne; Gong-Ping He; Hubert E Wang; Scott G Morham; Wesley I Sundquist
Journal:  J Cell Biol       Date:  2003-08-04       Impact factor: 10.539
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  4 in total

1.  HIV-1 Subtype C with PYxE Insertion Has Enhanced Binding of Gag-p6 to Host Cell Protein ALIX and Increased Replication Fitness.

Authors:  Robert van Domselaar; Duncan T Njenda; Rohit Rao; Anders Sönnerborg; Kamalendra Singh; Ujjwal Neogi
Journal:  J Virol       Date:  2019-04-17       Impact factor: 5.103

2.  Budding of retroviruses utilizing divergent L domains requires nucleocapsid.

Authors:  Nana F Bello; Vincent Dussupt; Paola Sette; Victoria Rudd; Kunio Nagashima; Frederic Bibollet-Ruche; Chaoping Chen; Ronald C Montelaro; Beatrice H Hahn; Fadila Bouamr
Journal:  J Virol       Date:  2012-02-15       Impact factor: 5.103

3.  Mutations in the feline immunodeficiency virus envelope glycoprotein confer resistance to a dominant-negative fragment of Tsg101 by enhancing infectivity and cell-to-cell virus transmission.

Authors:  Benjamin G Luttge; Prashant Panchal; Vinita Puri; Mary Ann Checkley; Eric O Freed
Journal:  Biochim Biophys Acta       Date:  2013-09-10

Review 4.  When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding.

Authors:  Kevin M Rose
Journal:  Viruses       Date:  2021-06-13       Impact factor: 5.048
  4 in total

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