Literature DB >> 21849291

Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection.

Scott D Kobayashi1, Natalia Malachowa, Adeline R Whitney, Kevin R Braughton, Donald J Gardner, Dan Long, Juliane Bubeck Wardenburg, Olaf Schneewind, Michael Otto, Frank R Deleo.   

Abstract

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are frequently associated with strains harboring genes encoding Panton-Valentine leukocidin (PVL). The role of PVL in the success of the epidemic CA-MRSA strain USA300 remains unknown. Here we developed a skin and soft tissue infection model in rabbits to test the hypothesis that PVL contributes to USA300 pathogenesis and compare it with well-established virulence determinants: alpha-hemolysin (Hla), phenol-soluble modulin-alpha peptides (PSMα), and accessory gene regulator (Agr). The data indicate that Hla, PSMα, and Agr contribute to the pathogenesis of USA300 skin infections in rabbits, whereas a role for PVL could not be detected.

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Year:  2011        PMID： 21849291      PMCID： PMC3156927          DOI： 10.1093/infdis/jir441

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  17 in total

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Journal:  Zentralbl Bakteriol       Date:  1999-04

2.  Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?

Authors:  Jovanka M Voyich; Michael Otto; Barun Mathema; Kevin R Braughton; Adeline R Whitney; Diane Welty; R Daniel Long; David W Dorward; Donald J Gardner; Gérard Lina; Barry N Kreiswirth; Frank R DeLeo
Journal:  J Infect Dis       Date:  2006-11-02       Impact factor: 5.226

3.  Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia.

Authors:  Juliane Bubeck Wardenburg; Taeok Bae; Michael Otto; Frank R Deleo; Olaf Schneewind
Journal:  Nat Med       Date:  2007-12       Impact factor: 53.440

4.  Transmembrane beta-barrel of staphylococcal alpha-toxin forms in sensitive but not in resistant cells.

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Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

5.  Methicillin-resistant S. aureus infections among patients in the emergency department.

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Journal:  N Engl J Med       Date:  2006-08-17       Impact factor: 91.245

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Authors:  A W Bernheimer
Journal:  Ann N Y Acad Sci       Date:  1965-07-23       Impact factor: 5.691

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Journal:  J Immunol       Date:  2005-09-15       Impact factor: 5.422

8.  Murine model of cutaneous infection with gram-positive cocci.

Authors:  C Bunce; L Wheeler; G Reed; J Musser; N Barg
Journal:  Infect Immun       Date:  1992-07       Impact factor: 3.441

9.  Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA.

Authors:  Rong Wang; Kevin R Braughton; Dorothee Kretschmer; Thanh-Huy L Bach; Shu Y Queck; Min Li; Adam D Kennedy; David W Dorward; Seymour J Klebanoff; Andreas Peschel; Frank R DeLeo; Michael Otto
Journal:  Nat Med       Date:  2007-11-11       Impact factor: 53.440

10.  Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections.

Authors:  Mark D King; Bianca J Humphrey; Yun F Wang; Ekaterina V Kourbatova; Susan M Ray; Henry M Blumberg
Journal:  Ann Intern Med       Date:  2006-03-07       Impact factor: 25.391
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  143 in total

Review 1.  Colonization, pathogenicity, host susceptibility, and therapeutics for Staphylococcus aureus: what is the clinical relevance?

Authors:  Steven Y C Tong; Luke F Chen; Vance G Fowler
Journal:  Semin Immunopathol       Date:  2011-12-11       Impact factor: 9.623

Review 2.  Virulence strategies of the dominant USA300 lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).

Authors:  Lance R Thurlow; Gauri S Joshi; Anthony R Richardson
Journal:  FEMS Immunol Med Microbiol       Date:  2012-03-05

3.  Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin.

Authors:  Angelino T Tromp; Michiel Van Gent; Pauline Abrial; Amandine Martin; Joris P Jansen; Carla J C De Haas; Kok P M Van Kessel; Bart W Bardoel; Elisabeth Kruse; Emilie Bourdonnay; Michael Boettcher; Michael T McManus; Christopher J Day; Michael P Jennings; Gérard Lina; François Vandenesch; Jos A G Van Strijp; Robert Jan Lebbink; Pieter-Jan A Haas; Thomas Henry; András N Spaan
Journal:  Nat Microbiol       Date:  2018-05-07       Impact factor: 17.745

Review 4.  Role of pore-forming toxins in bacterial infectious diseases.

Authors:  Ferdinand C O Los; Tara M Randis; Raffi V Aroian; Adam J Ratner
Journal:  Microbiol Mol Biol Rev       Date:  2013-06       Impact factor: 11.056

5.  ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.

Authors:  Seth M Daly; Bradley O Elmore; Jeffrey S Kavanaugh; Kathleen D Triplett; Mario Figueroa; Huzefa A Raja; Tamam El-Elimat; Heidi A Crosby; Jon K Femling; Nadja B Cech; Alexander R Horswill; Nicholas H Oberlies; Pamela R Hall
Journal:  Antimicrob Agents Chemother       Date:  2015-02-02       Impact factor: 5.191

Review 6.  Staphylococcus aureus pore-forming toxins: The interface of pathogen and host complexity.

Authors:  E Sachiko Seilie; Juliane Bubeck Wardenburg
Journal:  Semin Cell Dev Biol       Date:  2017-04-23       Impact factor: 7.727

Review 7.  Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors.

Authors:  András N Spaan; Jos A G van Strijp; Victor J Torres
Journal:  Nat Rev Microbiol       Date:  2017-04-19       Impact factor: 60.633

8.  Epicutaneous model of community-acquired Staphylococcus aureus skin infections.

Authors:  Ranjani Prabhakara; Oded Foreman; Roberto De Pascalis; Gloria M Lee; Roger D Plaut; Stanley Y Kim; Scott Stibitz; Karen L Elkins; Tod J Merkel
Journal:  Infect Immun       Date:  2013-02-04       Impact factor: 3.441

9.  Impact of the functional status of saeRS on in vivo phenotypes of Staphylococcus aureus sarA mutants.

Authors:  Karen E Beenken; Lara N Mrak; Agnieszka K Zielinska; Danielle N Atwood; Allister J Loughran; Linda M Griffin; K Alice Matthews; Allison M Anthony; Horace J Spencer; Robert A Skinner; Ginell R Post; Chia Y Lee; Mark S Smeltzer
Journal:  Mol Microbiol       Date:  2014-05-12       Impact factor: 3.501

10.  Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia.

Authors:  L Hua; J J Hilliard; Y Shi; C Tkaczyk; L I Cheng; X Yu; V Datta; S Ren; H Feng; R Zinsou; A Keller; T O'Day; Q Du; L Cheng; M Damschroder; G Robbie; J Suzich; C K Stover; B R Sellman
Journal:  Antimicrob Agents Chemother       Date:  2013-12-02       Impact factor: 5.191
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