PURPOSE: To investigate the association between kisspeptin 10 (Kp-10) levels and early pregnancy bleeding and perinatal outcome. METHODS: A total of 20 pregnant women with the complaint of vaginal bleeding during 7-18 gestational weeks and 20 healthy gestational week matched pregnant women were included in the study. Maternal plasma Kp-10 levels were measured with the enzyme immunoassay method. Adverse pregnancy outcomes like intrauterine growth restriction, preterm delivery, preeclampsia and low birth weight were evaluated in both groups. RESULTS: Maternal plasma Kp-10 levels (p = 0.01) and birth weight (p = 0.06) were found to be lower in women with bleeding. Intrauterine growth restriction, preterm delivery and intrauterine exitus were noted more commonly in women with bleeding (10 vs. 0%, 25 vs. 15% and 20 vs. 0%, p = 0.08). Preeclampsia were developed in 5% of both groups. Kp-10 levels showed positive correlation with gestational week (p = 0.02) and ALT levels (p = 0.02). CONCLUSION: [corrected] Kp-10 levels were found lower in women with early pregnancy bleeding.
PURPOSE: To investigate the association between kisspeptin 10 (Kp-10) levels and early pregnancy bleeding and perinatal outcome. METHODS: A total of 20 pregnant women with the complaint of vaginal bleeding during 7-18 gestational weeks and 20 healthy gestational week matched pregnant women were included in the study. Maternal plasma Kp-10 levels were measured with the enzyme immunoassay method. Adverse pregnancy outcomes like intrauterine growth restriction, preterm delivery, preeclampsia and low birth weight were evaluated in both groups. RESULTS: Maternal plasma Kp-10 levels (p = 0.01) and birth weight (p = 0.06) were found to be lower in women with bleeding. Intrauterine growth restriction, preterm delivery and intrauterine exitus were noted more commonly in women with bleeding (10 vs. 0%, 25 vs. 15% and 20 vs. 0%, p = 0.08). Preeclampsia were developed in 5% of both groups. Kp-10 levels showed positive correlation with gestational week (p = 0.02) and ALT levels (p = 0.02). CONCLUSION: [corrected] Kp-10 levels were found lower in women with early pregnancy bleeding.
Authors: James E Bowe; Thomas G Hill; Katharine F Hunt; Lorna If Smith; Sian Js Simpson; Stephanie A Amiel; Peter M Jones Journal: JCI Insight Date: 2019-10-17
Authors: Jovanna Tsoutsouki; Bijal Patel; Alexander N Comninos; Waljit S Dhillo; Ali Abbara Journal: Front Endocrinol (Lausanne) Date: 2022-07-19 Impact factor: 6.055
Authors: C N Jayasena; A Abbara; C Izzi-Engbeaya; A N Comninos; R A Harvey; J Gonzalez Maffe; Z Sarang; Z Ganiyu-Dada; A I Padilha; M Dhanjal; C Williamson; L Regan; M A Ghatei; S R Bloom; W S Dhillo Journal: J Clin Endocrinol Metab Date: 2014-12 Impact factor: 5.958