Literature DB >> 21847425

Myocardial fibrosis in an veteran endurance athlete.

Mathew Wilson1, Rory O'Hanlon, Sanjay Prasad, Sandeep Basavarajaiah, Nigel Stephens, Roxy Senior, Anthony Shaw, Sanjay Sharma, Gregory Whyte.   

Abstract

This study reports the cardiac structure and function of a lifelong male endurance athlete, who has run over 148 000 miles, who presented with symptoms of chest discomfort, dyspnoea and loss of competitive running performance. Importantly, the athlete documented several periods of regular intensive endurance activity while suffering with flu-like symptoms. Cardiovascular MRI demonstrated a pattern of late gadolinium enhancement, which indicated myocardial scarring as a result of previous myocarditis.Myocarditis is a non-ischaemic inflammatory disease of the myocardium associated with cardiac dysfunction and arrhythmogenic substrate. The clinical course of viral myocarditis is mostly insidious with limited cardiac inflammation and dysfunction. However, as in the present case, overwhelming inflammation may occur in a subset of patients leading to myocardial fibrosis due to recurrent inflammation.

Entities:  

Year:  2009        PMID: 21847425      PMCID: PMC3027633          DOI: 10.1136/bcr.12.2008.1345

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  9 in total

1.  Images in cardiovascular medicine. Myocarditis and sudden cardiac death in the young: extensive fibrosis suggested by cardiovascular magnetic resonance in vivo and confirmed post mortem.

Authors:  Sonya V Babu-Narayan; Karen P McCarthy; Siew Yen Ho; Alan G Magee; Philip J Kilner; Mary N Sheppard
Journal:  Circulation       Date:  2007-08-07       Impact factor: 29.690

2.  Arrhythmias and the athlete: mechanisms and clinical significance.

Authors:  Gregory P Whyte; Mary Sheppard; Keith P George; Robert E Shave; Mathew Wilson; Nigel Stephens; Roxy Senior; Sanjay Sharma
Journal:  Eur Heart J       Date:  2007-05-04       Impact factor: 29.983

3.  Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?

Authors:  G Whyte; M Sheppard; K George; R Shave; M Wilson; S Prasad; R O'Hanlon; S Sharma
Journal:  Br J Sports Med       Date:  2007-08-24       Impact factor: 13.800

4.  Interstitial fibrosis in the dilated non-ischaemic myocardium.

Authors:  A Brooks; V Schinde; A C Bateman; P J Gallagher
Journal:  Heart       Date:  2003-10       Impact factor: 5.994

Review 5.  Myocarditis: when to suspect and how to diagnose it in athletes.

Authors:  Cristina Chimenti; Maurizio Pieroni; Andrea Frustaci
Journal:  J Cardiovasc Med (Hagerstown)       Date:  2006-04       Impact factor: 2.160

6.  Interstitial collagen is increased in the non-infarcted human myocardium after myocardial infarction.

Authors:  P G Volders; I E Willems; J P Cleutjens; J W Arends; M G Havenith; M J Daemen
Journal:  J Mol Cell Cardiol       Date:  1993-11       Impact factor: 5.000

7.  Dilated cardiomyopathy is associated with an increase in the type I/type III collagen ratio: a quantitative assessment.

Authors:  M M Marijianowski; P Teeling; J Mann; A E Becker
Journal:  J Am Coll Cardiol       Date:  1995-05       Impact factor: 24.094

8.  Alterations in the extracellular matrix of the myocardium in essential hypertension.

Authors:  F J Pardo Mindán; A Panizo
Journal:  Eur Heart J       Date:  1993-11       Impact factor: 29.983

9.  Differentiation of heart failure related to dilated cardiomyopathy and coronary artery disease using gadolinium-enhanced cardiovascular magnetic resonance.

Authors:  J A McCrohon; J C C Moon; S K Prasad; W J McKenna; C H Lorenz; A J S Coats; D J Pennell
Journal:  Circulation       Date:  2003-06-23       Impact factor: 29.690

  9 in total
  2 in total

Review 1.  Cardiovascular function and the veteran athlete.

Authors:  M Wilson; R O'Hanlon; S Basavarajaiah; K George; D Green; P Ainslie; S Sharma; S Prasad; C Murrell; D Thijssen; A Nevill; G Whyte
Journal:  Eur J Appl Physiol       Date:  2010-06-17       Impact factor: 3.078

2.  Common causes of dyspnoea in athletes: a practical approach for diagnosis and management.

Authors:  James M Smoliga; Zahra S Mohseni; Jeffrey D Berwager; Eric J Hegedus
Journal:  Breathe (Sheff)       Date:  2016-06
  2 in total

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