Utility of some genetic marker in predicting response to lithium.

One hundred manic patients who were treated with lithium were studied to find out the possibility of genetic variations in response to lithium. Along with pedigree study, test of colour blindness and ABO blood grouping were used as genetic markers. The study supports the transmission by autosomal dominance with incomplete penetrance. There is no difference between the responders and non-responders in the mode of transmission and in the family history of mental illness, ABO blood grouping.