Literature DB >> 21846463

10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation.

Chiharu Sadakane1, Shuichi Muto, Koji Nakagawa, Shunsuke Ohnishi, Yayoi Saegusa, Miwa Nahata, Tomohisa Hattori, Masahiro Asaka, Hiroshi Takeda.   

Abstract

Rikkunshito (RKT), a Japanese traditional medicine, has been shown to stimulate food intake in rats with cisplatin-induced anorexia; however, the underlying mechanisms remain unknown. In this study, we investigated whether RKT is involved in the degradation of peripheral ghrelin. RKT inhibited decreases in plasma ghrelin level and enhanced acyl- to desacyl-ghrelin (A/D) ratio in cisplatin-treated rats. Several components of RKT demonstrated inhibitory activity against ghrelin deacylating enzymes. In addition, 10-gingerol, a component of RKT, inhibited exogenous ghrelin deacylation. Therefore, RKT may enhance plasma acyl-ghrelin level, at least in part, by inhibiting the circulating ghrelin degrading enzyme.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21846463     DOI： 10.1016/j.bbrc.2011.08.002

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

1.  Prospective, randomized, cross-over pilot study of the effects of Rikkunshito, a Japanese traditional herbal medicine, on anorexia and plasma-acylated ghrelin levels in lung cancer patients undergoing cisplatin-based chemotherapy.

Authors:  Tomoharu Yoshiya; Takahiro Mimae; Masaoki Ito; Shinsuke Sasada; Yasuhiro Tsutani; Kenichi Satoh; Takeshi Masuda; Yoshihiro Miyata; Noboru Hattori; Morihito Okada
Journal:  Invest New Drugs       Date:  2019-08-19       Impact factor: 3.850

2.  Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs.

Authors:  Mitsuhiro Yanai; Erito Mochiki; Atsushi Ogawa; Hiroki Morita; Yoshitaka Toyomasu; Kyoichi Ogata; Yuichi Tabe; Hiroyuki Ando; Tetsuro Ohno; Takayuki Asao; Tohru Aomori; Yukiyoshi Fujita; Hiroyuki Kuwano
Journal:  J Gastroenterol       Date:  2012-10-10       Impact factor: 7.527

3.  Effect of rikkunshito, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy.

Authors:  Shuji Takiguchi; Yuichiro Hiura; Tsuyoshi Takahashi; Yukinori Kurokawa; Makoto Yamasaki; Kiyokazu Nakajima; Hiroshi Miyata; Masaki Mori; Hiroshi Hosoda; Kenji Kangawa; Yuichiro Doki
Journal:  Gastric Cancer       Date:  2012-08-16       Impact factor: 7.370

Review 4.  A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction.

Authors:  Yayoi Saegusa; Tomohisa Hattori; Miwa Nahata; Chihiro Yamada; Hiroshi Takeda
Journal:  Evid Based Complement Alternat Med       Date:  2015-05-03       Impact factor: 2.629

5.  Patterns of Brain Activation and Meal Reduction Induced by Abdominal Surgery in Mice and Modulation by Rikkunshito.

Authors:  Lixin Wang; Sachiko Mogami; Seiichi Yakabi; Hiroshi Karasawa; Chihiro Yamada; Koji Yakabi; Tomohisa Hattori; Yvette Taché
Journal:  PLoS One       Date:  2015-09-30       Impact factor: 3.240

6.  Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study.

Authors:  Hiroyuki Kitagawa; Masaya Munekage; Takashi Matsumoto; Chiharu Sadakane; Miwako Fukutake; Katsuyuki Aoki; Junko Watanabe; Kazuya Maemura; Tomohisa Hattori; Yosio Kase; Yasuhito Uezono; Akio Inui; Kazuhiro Hanazaki
Journal:  PLoS One       Date:  2015-07-17       Impact factor: 3.240

7.  Traditional Japanese herbal medicine rikkunshito increases food intake and plasma acylated ghrelin levels in patients with esophageal cancer treated by cisplatin-based chemotherapy.

Authors:  Yoich Hamai; Tomoharu Yoshiya; Jun Hihara; Manabu Emi; Takaoki Furukawa; Ichiko Yamakita; Yuta Ibuki; Morihito Okada
Journal:  J Thorac Dis       Date:  2019-06       Impact factor: 2.895

Review 8.  Cancer cachexia--pathophysiology and management.

Authors:  Hajime Suzuki; Akihiro Asakawa; Haruka Amitani; Norifumi Nakamura; Akio Inui
Journal:  J Gastroenterol       Date:  2013-03-20       Impact factor: 7.527

Review 9.  Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application.

Authors:  Kazunari Tominaga; Tetsuo Arakawa
Journal:  J Gastroenterol       Date:  2013-03-16       Impact factor: 7.527

10.  First nationwide attitude survey of Japanese physicians on the use of traditional Japanese medicine (kampo) in cancer treatment.

Authors:  A Ito; K Munakata; Y Imazu; K Watanabe
Journal:  Evid Based Complement Alternat Med       Date:  2012-11-22       Impact factor: 2.629
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.