Mehdi Parva1, Kathleen Lamb2, Deric C Savior3, Paul Gilman3, Michael Belden4. 1. Department of Obstetrics and Gynecology, Lankenau Hospital, Wynnewood PA. 2. Jefferson Medical College, Thomas Jefferson University, Philadelphia PA. 3. Department of Hematology and Oncology, Lankenau Hospital, Wynnewood PA. 4. Department of Obstetrics and Gynecology, Lankenau Hospital, Wynnewood PA; Jefferson Medical College, Thomas Jefferson University, Philadelphia PA.
Abstract
BACKGROUND: Primary gynaecologic non-Hodgkin's lymphomas are rare. We present a case of primary large B-cell lymphoma localized to the lower uterine segment and endocervical stroma that was successfully treated with chemotherapy and immunotherapy. Treatment was followed by a disease-free interval and successful term vaginal delivery. CASE: A 21-year-old nulliparous woman presented with dysfunctional uterine bleeding. Radiologic assessment of a posterior lower uterine segment mass and pathologic evaluation of cervical biopsies demonstrated diffuse large B-cell lymphoma involving the endocervical stroma. The patient was treated with chemotherapy and immunotherapy. She had a normal, uncomplicated full-term pregnancy and spontaneous vaginal delivery six years after treatment. CONCLUSION: Aggressive diagnosis and treatment of primary non-Hodgkin's lymphomas of the cervix do not preclude the possibility of a successful pregnancy and term vaginal delivery.
BACKGROUND: Primary gynaecologic non-Hodgkin's lymphomas are rare. We present a case of primary large B-cell lymphoma localized to the lower uterine segment and endocervical stroma that was successfully treated with chemotherapy and immunotherapy. Treatment was followed by a disease-free interval and successful term vaginal delivery. CASE: A 21-year-old nulliparous woman presented with dysfunctional uterine bleeding. Radiologic assessment of a posterior lower uterine segment mass and pathologic evaluation of cervical biopsies demonstrated diffuse large B-cell lymphoma involving the endocervical stroma. The patient was treated with chemotherapy and immunotherapy. She had a normal, uncomplicated full-term pregnancy and spontaneous vaginal delivery six years after treatment. CONCLUSION: Aggressive diagnosis and treatment of primary non-Hodgkin's lymphomas of the cervix do not preclude the possibility of a successful pregnancy and term vaginal delivery.
Authors: Guglielmo Stabile; Lara Sancin; Pierino Boschian Bailo; Chiara Ripepi; Andrea Romano; Stefania Carlucci; Giuseppe Ricci Journal: Int J Environ Res Public Health Date: 2022-09-18 Impact factor: 4.614