Literature DB >> 2184445

Drug transport in the central nervous system: role of carriers.

R Spector1.   

Abstract

The rate of entry into and distribution of many drugs in the mammalian brain cannot be explained by the physicochemical characteristics of these drugs taking into account the anatomy of the blood-brain barrier. Rather, specialized mechanisms (carriers) in the central nervous system have been sought after and characterized. These carriers explain the observed pharmacokinetic behavior of many drugs in brain. This review summarizes these data in the context of the blood-brain barrier and focuses on several broad principles and selected examples.

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Year:  1990        PMID： 2184445     DOI： 10.1159/000138632

Source DB:  PubMed          Journal:  Pharmacology        ISSN： 0031-7012            Impact factor:   2.547


  3 in total

1.  Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.

Authors:  V V Rao; J L Dahlheimer; M E Bardgett; A Z Snyder; R A Finch; A C Sartorelli; D Piwnica-Worms
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

2.  Microdialysis studies of the distribution of stavudine into the central nervous system in the freely-moving rat.

Authors:  Z Yang; R C Brundage; R H Barbhaiya; R J Sawchuk
Journal:  Pharm Res       Date:  1997-07       Impact factor: 4.200

3.  In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors.

Authors:  R Masereeuw; U Jaehde; M W Langemeijer; A G de Boer; D D Breimer
Journal:  Pharm Res       Date:  1994-02       Impact factor: 4.200
  3 in total

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