Rongrong Tan1, Danhua Pu, Lipeng Liu, Jiayin Liu, Jie Wu. 1. The State Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People's Republic of China.
Abstract
OBJECTIVE: To evaluate serum inhibin B as a predictor of poor ovarian response in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) and to compare it with the performance of antimüllerian hormone (AMH). DESIGN: Meta-analysis. SETTING: University hospital. PATIENT(S): Patients undergoing IVF. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Poor ovarian response in controlled ovarian hyperstimulation (COH). RESULT(S): Fifteen studies on serum inhibin B and 12 studies on AMH were selected for meta-analysis. Both basal and stimulated inhibin B levels were statistically significantly lower in poor ovarian responders than in controls. The estimated summary receiver operating characteristic (ROC) curves suggested that stimulated inhibin B was more accurate than basal inhibin B and AMH in the prediction of poor ovarian response. CONCLUSION(S): Both basal and stimulated serum inhibin B levels are lower in poor responders than in controls. Compared with AMH, stimulated inhibin B is a more accurate predictor of ovarian response in patients undergoing IVF, making it a potentially useful tool in future IVF practice.
OBJECTIVE: To evaluate serum inhibin B as a predictor of poor ovarian response in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) and to compare it with the performance of antimüllerian hormone (AMH). DESIGN: Meta-analysis. SETTING: University hospital. PATIENT(S): Patients undergoing IVF. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Poor ovarian response in controlled ovarian hyperstimulation (COH). RESULT(S): Fifteen studies on serum inhibin B and 12 studies on AMH were selected for meta-analysis. Both basal and stimulated inhibin B levels were statistically significantly lower in poor ovarian responders than in controls. The estimated summary receiver operating characteristic (ROC) curves suggested that stimulated inhibin B was more accurate than basal inhibin B and AMH in the prediction of poor ovarian response. CONCLUSION(S): Both basal and stimulated serum inhibin B levels are lower in poor responders than in controls. Compared with AMH, stimulated inhibin B is a more accurate predictor of ovarian response in patients undergoing IVF, making it a potentially useful tool in future IVF practice.