| Literature DB >> 21842838 |
Yasufumi Imae1, Kentaro Takada, Shuhei Murayama, Shigeru Okada, Yuji Ise, Shigeki Matsunaga.
Abstract
Two architecturally new isoquinolines, jasisoquinolines A and B, were isolated from a marine sponge Jaspis sp. as cathepsin B inhibitors. Their structures were determined by a combination of spectroscopic analyses and chemical methods. Both jasisoquinolines A and B inhibit cathepsin B with an IC(50) value of 10 μg/mL.Entities:
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Year: 2011 PMID： 21842838 DOI： 10.1021/ol201823w
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005