Literature DB >> 21842169

The streptozotocin-induced rat model of diabetes mellitus evidences significant reduction of myosin-Va expression in the brain.

Alice Vieira da Costa1, Luciana Karen Calábria, Rafael Nascimento, Washington João Carvalho, Luiz Ricardo Goulart, Foued Salmen Espindola.   

Abstract

Diabetes mellitus is a disease characterized by increased glucose levels in the blood. Hyperglycemia causes damage to the brain tissue, and induces significant changes in synaptic transmission. In this investigation, we have found a significant alteration in the expression of the molecular motor involved in the synaptic vesicles transport, myosin-Va, and its distribution in rat brains of streptozotocin-induced diabetes model. Brains were removed after 20 days, homogenized and analysed by Western blotting, qRT-PCR and immunohistochemistry. Myosin-Va presented significantly lower levels of both mRNA and protein in diabetic than those observed in non-diabetic animals. Moreover, neuronal and glial cells of the occipital and frontal cortex exhibited decreased myosin-Va immunostaining in diabetic rat brains. In conclusion, diabetic rat brains displayed altered expression and distribution of myosin-Va, and these finding may contribute to the basic understanding about this myosin role in brain function related to diabetes.

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Year:  2011        PMID： 21842169     DOI： 10.1007/s11011-011-9259-5

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  29 in total

1.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

2.  Immunocytochemical analysis of synaptic proteins provides new insights into diabetes-mediated plasticity in the rat hippocampus.

Authors:  C A Grillo; G G Piroli; G E Wood; L R Reznikov; B S McEwen; L P Reagan
Journal:  Neuroscience       Date:  2005-10-13       Impact factor: 3.590

Review 3.  Glucose neurotoxicity.

Authors:  David R Tomlinson; Natalie J Gardiner
Journal:  Nat Rev Neurosci       Date:  2008-01       Impact factor: 34.870

Review 4.  Diabetes-, stress- and ageing-related changes in synaptic plasticity in hippocampus and neocortex--the same metaplastic process?

Authors:  Alain Artola
Journal:  Eur J Pharmacol       Date:  2008-03-04       Impact factor: 4.432

5.  Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats.

Authors:  Yoshiko Takagishi; Kouichi Hashimoto; Tetsuro Kayahara; Masahiko Watanabe; Hiroyuki Otsuka; Akira Mizoguchi; Masanobu Kano; Yoshiharu Murata
Journal:  Dev Neurobiol       Date:  2007-06       Impact factor: 3.964

6.  Specific changes of somatostatin mRNA expression in the frontal cortex and hippocampus of diabetic rats.

Authors:  Zhang XiaoMing; Zhu Xi; Shen Fang; Zhou Jilin
Journal:  J Anat       Date:  2004-03       Impact factor: 2.610

7.  Proteomic analysis of mitochondrial proteins in a mouse model of type 2 diabetes.

Authors:  M F Essop; W A Chan; S Hattingh
Journal:  Cardiovasc J Afr       Date:  2010-09-11       Impact factor: 1.167

8.  Structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats.

Authors:  Juan P Hernández-Fonseca; Jaimar Rincón; Adriana Pedreañez; Ninoska Viera; José L Arcaya; Edgardo Carrizo; Jesús Mosquera
Journal:  Exp Diabetes Res       Date:  2009-10-01

9.  Evaluation of Bcl-2 family gene expression and Caspase-3 activity in hippocampus STZ-induced diabetic rats.

Authors:  Iraj Jafari Anarkooli; Mojtaba Sankian; Shahriar Ahmadpour; Abdol-ReZa Varasteh; Hossein Haghir
Journal:  Exp Diabetes Res       Date:  2008-10-12

10.  Biochemical and immunological characterization of p190-calmodulin complex from vertebrate brain: a novel calmodulin-binding myosin.

Authors:  F S Espindola; E M Espreafico; M V Coelho; A R Martins; F R Costa; M S Mooseker; R E Larson
Journal:  J Cell Biol       Date:  1992-07       Impact factor: 10.539
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  6 in total

1.  Cargo Transport by Two Coupled Myosin Va Motors on Actin Filaments and Bundles.

Authors:  M Yusuf Ali; Andrej Vilfan; Kathleen M Trybus; David M Warshaw
Journal:  Biophys J       Date:  2016-11-15       Impact factor: 4.033

2.  Neuroprotective effects of Pouteria ramiflora (Mart.) Radlk (Sapotaceae) extract on the brains of rats with streptozotocin-induced diabetes.

Authors:  Alice Vieira da Costa; Luciana Karen Calábria; Fabiana Barcelos Furtado; Neire Moura de Gouveia; Renato José da Silva Oliveira; Vanessa Neves de Oliveira; Marcelo Emilio Beletti; Foued Salmen Espindola
Journal:  Metab Brain Dis       Date:  2013-03-07       Impact factor: 3.584

3.  Myosin Va but Not nNOSα is Significantly Reduced in Jejunal Musculomotor Nerve Terminals in Diabetes Mellitus.

Authors:  Arun Chaudhury; Marcilio Hubner De Miranda-Neto; Renata Virginia Fernandes Pereira; Jacqueline Nelisis Zanoni
Journal:  Front Med (Lausanne)       Date:  2014-06-20

4.  Myosins Are Differentially Expressed under Oxidative Stress in Chronic Streptozotocin-Induced Diabetic Rat Brains.

Authors:  Luciana Karen Calábria; Alice Vieira da Costa; Renato José da Silva Oliveira; Simone Ramos Deconte; Rafael Nascimento; Washington João de Carvalho; Vanessa Neves de Oliveira; Carlos Alberto Arcaro Filho; Luciana Rezende Alves de Oliveira; Luiz Ricardo Goulart; Foued Salmen Espindola
Journal:  ISRN Neurosci       Date:  2013-09-24

5.  Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features.

Authors:  Marzia Pesaresi; Silvia Giatti; Roberto Spezzano; Simone Romano; Silvia Diviccaro; Tiziana Borsello; Nico Mitro; Donatella Caruso; Luis Miguel Garcia-Segura; Roberto Cosimo Melcangi
Journal:  Biol Sex Differ       Date:  2018-01-19       Impact factor: 5.027

6.  Myosin Va plays a role in nitrergic smooth muscle relaxation in gastric fundus and corpora cavernosa of penis.

Authors:  Arun Chaudhury; Vivian Cristofaro; Josephine A Carew; Raj K Goyal; Maryrose P Sullivan
Journal:  PLoS One       Date:  2014-02-06       Impact factor: 3.240
  6 in total

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