Literature DB >> 21841938

A PARYLENE-BASED MICROELECTRODE ARRAY IMPLANT FOR SPINAL CORD STIMULATION IN RATS.

Mandheerej S Nandra1, Igor A Lavrov, V Reggie Edgerton, Yu-Chong Tai.   

Abstract

The design and fabrication of an epidural spinal cord implant using a parylene-based microelectrode array is presented. Rats with hindlimb paralysis from a complete spinal cord transection were implanted with the device and studied for up to eight weeks, where we have demonstrated recovery of hindlimb stepping functionality through pulsed stimulation. The microelectrode array allows for a high degree of freedom and specificity in selecting the site of stimulation compared to wire-based implants, and triggers varied biological responses that can lead to an increased understanding of the spinal cord and locomotion recovery for victims of spinal cord injury.

Entities:  

Year:  2011        PMID： 21841938      PMCID： PMC3154740          DOI： 10.1109/MEMSYS.2011.5734598

Source DB:  PubMed          Journal:  Conf Proc IEEE Eng Med Biol Soc        ISSN： 1557-170X


  3 in total

1.  A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord.

Authors:  Kathleen W Meacham; Richard J Giuly; Liang Guo; Shawn Hochman; Stephen P DeWeerth
Journal:  Biomed Microdevices       Date:  2008-04       Impact factor: 2.838

2.  Hindlimb stepping movements in complete spinal rats induced by epidural spinal cord stimulation.

Authors:  R M Ichiyama; Yu P Gerasimenko; H Zhong; R R Roy; V R Edgerton
Journal:  Neurosci Lett       Date:  2005-08-05       Impact factor: 3.046

3.  Step training reinforces specific spinal locomotor circuitry in adult spinal rats.

Authors:  Ronaldo M Ichiyama; Grégoire Courtine; Yury P Gerasimenko; Grace J Yang; Rubia van den Brand; Igor A Lavrov; Hui Zhong; Roland R Roy; V Reggie Edgerton
Journal:  J Neurosci       Date:  2008-07-16       Impact factor: 6.167
  3 in total
  6 in total

1.  Integrating multiple sensory systems to modulate neural networks controlling posture.

Authors:  I Lavrov; Y Gerasimenko; J Burdick; H Zhong; R R Roy; V R Edgerton
Journal:  J Neurophysiol       Date:  2015-10-07       Impact factor: 2.714

2.  Fabrication and Characterization of 3D Multi-Electrode Array on Flexible Substrate for In Vivo EMG Recording from Expiratory Muscle of Songbird.

Authors:  Muneeb Zia; Bryce Chung; Samuel J Sober; Muhannad S Bakir
Journal:  Tech Dig Int Electron Devices Meet       Date:  2019-01-17

3.  Electrophysiological mapping of rat sensorimotor lumbosacral spinal networks after complete paralysis.

Authors:  Parag Gad; Roland R Roy; Jaehoon Choe; Hui Zhong; Mandheeraj Singh Nandra; Yu-Chong Tai; Yury Gerasimenko; V Reggie Edgerton
Journal:  Prog Brain Res       Date:  2015-03-19       Impact factor: 2.453

4.  Wettability and Surface Roughness of Parylene C on Three-Dimensional-Printed Photopolymers.

Authors:  Fan-Chun Hsieh; Chien-Yao Huang; Yen-Pei Lu
Journal:  Materials (Basel)       Date:  2022-06-11       Impact factor: 3.748

5.  Development of a multi-electrode array for spinal cord epidural stimulation to facilitate stepping and standing after a complete spinal cord injury in adult rats.

Authors:  Parag Gad; Jaehoon Choe; Mandheerej Singh Nandra; Hui Zhong; Roland R Roy; Yu-Chong Tai; V Reggie Edgerton
Journal:  J Neuroeng Rehabil       Date:  2013-01-21       Impact factor: 4.262

6.  The Role of Functional Neuroanatomy of the Lumbar Spinal Cord in Effect of Epidural Stimulation.

Authors:  Carlos A Cuellar; Aldo A Mendez; Riazul Islam; Jonathan S Calvert; Peter J Grahn; Bruce Knudsen; Tuan Pham; Kendall H Lee; Igor A Lavrov
Journal:  Front Neuroanat       Date:  2017-09-22       Impact factor: 3.856
  6 in total

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