Literature DB >> 21841107

Folic acid and colorectal cancer: unwarranted fears.

Gideon Koren1.   

Abstract

QUESTION: Some of my female patients are afraid of taking folic acid because they "fear cancer." What is the evidence for this? ANSWER: Theoretical evidence in experimental models is sharply contrasted by 3 recent meta-analyses of randomized and observational studies. Women planning to become pregnant should supplement with the folate dose they need to prevent neural tube defects.

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Year:  2011        PMID： 21841107      PMCID： PMC3155439     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  15 in total

Review 1.  Fear of future illness, chemical AIDS, and cancerphobia: a review.

Authors:  R S Brown; P R Lees-Haley
Journal:  Psychol Rep       Date:  1992-08

Review 2.  Quantifying the effect of folic acid.

Authors:  N J Wald; M R Law; J K Morris; D S Wald
Journal:  Lancet       Date:  2001-12-15       Impact factor: 79.321

Review 3.  Folic acid supplementation and cancer risk: point.

Authors:  Young-In Kim
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-09       Impact factor: 4.254

4.  Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group.

Authors: 
Journal:  Lancet       Date:  1991-07-20       Impact factor: 79.321

Review 5.  Folate intake and the risk of colorectal cancer: a systematic review and meta-analysis.

Authors:  Deborah A Kennedy; Seth J Stern; Myla Moretti; Ilan Matok; Moumita Sarkar; Cheri Nickel; Gideon Koren
Journal:  Cancer Epidemiol       Date:  2010-12-21       Impact factor: 2.984

6.  Folate levels and neural tube defects. Implications for prevention.

Authors:  L E Daly; P N Kirke; A Molloy; D G Weir; J M Scott
Journal:  JAMA       Date:  1995-12-06       Impact factor: 56.272

7.  Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.

Authors:  A E Czeizel; I Dudás
Journal:  N Engl J Med       Date:  1992-12-24       Impact factor: 91.245

8.  Reduction in neural-tube defects after folic acid fortification in Canada.

Authors:  Philippe De Wals; Fassiatou Tairou; Margot I Van Allen; Soo-Hong Uh; R Brian Lowry; Barbara Sibbald; Jane A Evans; Michiel C Van den Hof; Pamela Zimmer; Marian Crowley; Bridget Fernandez; Nora S Lee; Theophile Niyonsenga
Journal:  N Engl J Med       Date:  2007-07-12       Impact factor: 91.245

9.  Folate fortification and supplementation--are we there yet?

Authors:  Benjamin Bar-Oz; Gideon Koren; Patricia Nguyen; Bhushan M Kapur
Journal:  Reprod Toxicol       Date:  2008-05-03       Impact factor: 3.143

10.  RETIRED: Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies.

Authors:  R Douglas Wilson
Journal:  J Obstet Gynaecol Can       Date:  2007-12
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  2 in total

1.  Comprehensive interpretation of in vitro micronucleus test results for 292 chemicals: from hazard identification to risk assessment application.

Authors:  Byron Kuo; Marc A Beal; John W Wills; Paul A White; Francesco Marchetti; Andy Nong; Tara S Barton-Maclaren; Keith Houck; Carole L Yauk
Journal:  Arch Toxicol       Date:  2022-04-21       Impact factor: 6.168

2.  Efficacy and safety of chemopreventive agents on colorectal cancer incidence and mortality: systematic review and network meta-analysis.

Authors:  Sajesh K Veettil; Peerawat Jinatongthai; Surakit Nathisuwan; Nattawat Teerawattanapong; Siew Mooi Ching; Kean Ghee Lim; Surasak Saokaew; Pochamana Phisalprapa; Christopher M Reid; Nathorn Chaiyakunapruk
Journal:  Clin Epidemiol       Date:  2018-10-10       Impact factor: 4.790
  2 in total

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