Literature DB >> 2184091

Genetic linkage and complex diseases, with special reference to psychiatric disorders.

N Risch1.   

Abstract

Recent linkage findings for psychiatric disorders, in particular schizophrenia, manic-depression, and Alzheimer disease, have raised a number of important conceptual issues regarding the genetic etiology of these diseases, as well as the appropriate interpretation of linkage results in studying complex diseases. Perspectives on mode of inheritance, genetic heterogeneity, and phenotypic variation are given.

Entities:  

Mesh：

Year:  1990        PMID： 2184091     DOI： 10.1002/gepi.1370070103

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  48 in total

Review 1.  Genetics of schizophrenia and the new millennium: progress and pitfalls.

Authors:  M Baron
Journal:  Am J Hum Genet       Date:  2001-01-17       Impact factor: 11.025

Review 2.  Heterogeneity and the genetics of autism.

Authors:  P Szatmari
Journal:  J Psychiatry Neurosci       Date:  1999-03       Impact factor: 6.186

Review 3.  Paternal factors and schizophrenia risk: de novo mutations and imprinting.

Authors:  D Malaspina
Journal:  Schizophr Bull       Date:  2001       Impact factor: 9.306

4.  The allure of genetic explanations.

Authors:  J S Alper; M R Natowicz
Journal:  BMJ       Date:  1992-09-19

5.  Epigenetics as a unifying principle in the aetiology of complex traits and diseases.

Authors:  Arturas Petronis
Journal:  Nature       Date:  2010-06-10       Impact factor: 49.962

6.  A candidate phenotype for familial dyslexia.

Authors:  P H Wolff
Journal:  Eur Child Adolesc Psychiatry       Date:  1999       Impact factor: 4.785

7.  Sensitivity of lod scores to changes in diagnostic status.

Authors:  S E Hodge; D A Greenberg
Journal:  Am J Hum Genet       Date:  1992-05       Impact factor: 11.025

Review 8.  Current perspectives on the genetics of unipolar depression.

Authors:  S O Moldin; T Reich; J P Rice
Journal:  Behav Genet       Date:  1991-05       Impact factor: 2.805

Review 9.  The genetics of schizophrenia and bipolar disorder: dissecting psychosis.

Authors:  N Craddock; M C O'Donovan; M J Owen
Journal:  J Med Genet       Date:  2005-03       Impact factor: 6.318

10.  Association of variants in DISC1 with psychosis-related traits in a large population cohort.

Authors:  Liisa Tomppo; William Hennah; Jouko Miettunen; Marjo-Riitta Järvelin; Juha Veijola; Samuli Ripatti; Päivi Lahermo; Dirk Lichtermann; Leena Peltonen; Jesper Ekelund
Journal:  Arch Gen Psychiatry       Date:  2009-02
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