| Literature DB >> 21840717 |
Xiang-Jing Wang1, Ji Zhang, Chong-Xi Liu, Dian-Liang Gong, Hui Zhang, Ji-Dong Wang, Yi-Jun Yan, Wen-Sheng Xiang.
Abstract
A novel macrocyclic lactone (1) was isolated from the fermentation broth of Streptomycesmicroflavus neau3, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed high acaricidal activity against adult mites (IC(50)=11.1 μg mL(-1)), and nematocidal activity against Caenorhabditis elegans (IC(50)=17.4 μg mL(-1)), especially the acaricidal activity against mite eggs with an IC(50) of 37.1 μg mL(-1), which was relative higher than that of the commercial acaricide and nematocide milbemycins A(3)/A(4).Entities:
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Year: 2011 PMID： 21840717 DOI： 10.1016/j.bmcl.2011.07.070
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823