| Literature DB >> 2184068 |
A Ceriello1, D Giugliano, A Quatraro, E Marchi, M Barbanti, P Lefèbvre.
Abstract
In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.Entities:
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Year: 1990 PMID： 2184068 DOI： 10.1007/bf00404044
Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122