| Literature DB >> 21840484 |
Qi Cao1, Ram-Shankar Mani, Bushra Ateeq, Saravana M Dhanasekaran, Irfan A Asangani, John R Prensner, Jung H Kim, J Chad Brenner, Xiaojun Jing, Xuhong Cao, Rui Wang, Yong Li, Arun Dahiya, Lei Wang, Mithil Pandhi, Robert J Lonigro, Yi-Mi Wu, Scott A Tomlins, Nallasivam Palanisamy, Zhaohui Qin, Jindan Yu, Christopher A Maher, Sooryanarayana Varambally, Arul M Chinnaiyan.
Abstract
Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group (PcG) proteins including EZH2, a PRC2 component, are upregulated in various cancer types, implicating their role in tumorigenesis. Here, we have identified several microRNAs (miRNAs) that are repressed by EZH2. These miRNAs, in turn, regulate the expression of PRC1 proteins BMI1 and RING2. We found that ectopic overexpression of EZH2-regulated miRNAs attenuated cancer cell growth and invasiveness, and abrogated cancer stem cell properties. Importantly, expression analysis revealed an inverse correlation between miRNA and PRC protein levels in cell culture and prostate cancer tissues. Taken together, our data have uncovered a coordinate regulation of PRC1 and PRC2 activities that is mediated by miRNAs.Entities:
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Year: 2011 PMID： 21840484 PMCID： PMC3157014 DOI： 10.1016/j.ccr.2011.06.016
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743