Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Targeting chemokine receptors in chronic inflammatory diseases: an extensive review.

Literature DB >> 21839114

Targeting chemokine receptors in chronic inflammatory diseases: an extensive review.

Pim J Koelink¹, Saskia A Overbeek, Saskia Braber, Petra de Kruijf, Gert Folkerts, Martine J Smit, Aletta D Kraneveld.

Abstract

The traffic of the different types of immune cells is an important aspect in the immune response. Chemokines are soluble peptides that are able to attract cells by interaction with chemokine receptors on their target cells. Several different chemokines and receptors exist enabling the specific trafficking of different immune cells. In chronic inflammatory disorders there is abundance of immune cells present at the inflammatory site. This review focuses on the role of chemokine receptors in chronic inflammatory disorders of the lungs, intestine, joints, skin and nervous system and the potential of targeting these receptors as therapeutic intervention in these disorders.

Mesh：

Substances：

Year: 2011 PMID： 21839114 DOI： 10.1016/j.pharmthera.2011.06.008

Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310

Keyword Cloud
Cited

48 in total

Review 1. Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring.

Authors: Peter Adam Rees; Nicholas Stuart Greaves; Mohamed Baguneid; Ardeshir Bayat
Journal: Adv Wound Care (New Rochelle) Date: 2015-11-01 Impact factor: 4.730

Review 2. Chemokine Regulation of Neutrophil Infiltration of Skin Wounds.

Authors: Yingjun Su; Ann Richmond
Journal: Adv Wound Care (New Rochelle) Date: 2015-11-01 Impact factor: 4.730

3. Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.

Authors: Alexis D Greene; Jessica A Kendziorski; Jeanette M Buckholz; Liang Niu; Changchun Xie; Susan M Pinney; Katherine A Burns
Journal: Reprod Toxicol Date: 2018-12-21 Impact factor: 3.143

4. Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES.

Authors: Pauline Bonvin; Franck Gueneau; Vanessa Buatois; Maud Charreton-Galby; Stanley Lasch; Marie Messmer; Urs Christen; Andrew D Luster; Zoë Johnson; Walter Ferlin; Marie Kosco-Vilbois; Amanda Proudfoot; Nicolas Fischer
Journal: J Biol Chem Date: 2017-01-30 Impact factor: 5.157

5. Alternative C-terminal helix orientation alters chemokine function: structure of the anti-angiogenic chemokine, CXCL4L1.

Authors: Je-Hung Kuo; Ya-Ping Chen; Jai-Shin Liu; Alexandre Dubrac; Cathy Quemener; Hervé Prats; Andreas Bikfalvi; Wen-guey Wu; Shih-Che Sue
Journal: J Biol Chem Date: 2013-03-27 Impact factor: 5.157

Targeting chemokine receptors in chronic inflammatory diseases: an extensive review.

Review 1. Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring.

Review 2. Chemokine Regulation of Neutrophil Infiltration of Skin Wounds.

3. Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.

4. Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES.

5. Alternative C-terminal helix orientation alters chemokine function: structure of the anti-angiogenic chemokine, CXCL4L1.

6. Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor.

7. The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

8. The CCL2 chemokine is a negative regulator of autophagy and necrosis in luminal B breast cancer cells.

9. Pathway and mechanism of drug binding to chemokine receptors revealed by accelerated molecular simulations.

10. Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus.