OBJECTIVE: To evaluate the effects of treatment on respiratory rate, serum natriuretic peptide concentrations, and Doppler echocardiographic indices of left ventricular filling pressure in dogs with congestive heart failure (CHF) secondary to degenerative mitral valve disease (MVD) and dilated cardiomyopathy (DCM). DESIGN: Prospective cohort study. ANIMALS: 63 client-owned dogs. PROCEDURES: Physical examination, thoracic radiography, analysis of natriuretic peptide concentrations, and Doppler echocardiography were performed twice, at baseline (examination 1) and 5 to 14 days later (examination 2). Home monitoring of respiratory rate was performed by the owners between examinations. RESULTS: In dogs with MVD, resolution of CHF was associated with a decrease in respiratory rate, serum N-terminal probrain natriuretic peptide (NT-proBNP) concentration, and diastolic functional class and an increase of the ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic lateral mitral annulus motion (E:Ea Lat). In dogs with DCM, resolution of CHF was associated with a decrease in respiratory rate and serum NT-proBNP concentration and significant changes in 7 Doppler echocardiographic variables, including a decrease of E:Ea Lat and the ratio of peak velocity of early diastolic transmitral flow to isovolumic relaxation time. Only respiratory rate predicted the presence of CHF at examination 2 with high accuracy. CONCLUSIONS AND CLINICAL RELEVANCE: Resolution of CHF was associated with predictable changes in respiratory rate, serum NT-proBNP concentration, and selected Doppler echocardiographic variables in dogs with DCM and MVD. Home monitoring of respiratory rate was simple and was the most useful in the assessment of successful treatment of CHF.
OBJECTIVE: To evaluate the effects of treatment on respiratory rate, serum natriuretic peptide concentrations, and Doppler echocardiographic indices of left ventricular filling pressure in dogs with congestive heart failure (CHF) secondary to degenerative mitral valve disease (MVD) and dilated cardiomyopathy (DCM). DESIGN: Prospective cohort study. ANIMALS: 63 client-owned dogs. PROCEDURES: Physical examination, thoracic radiography, analysis of natriuretic peptide concentrations, and Doppler echocardiography were performed twice, at baseline (examination 1) and 5 to 14 days later (examination 2). Home monitoring of respiratory rate was performed by the owners between examinations. RESULTS: In dogs with MVD, resolution of CHF was associated with a decrease in respiratory rate, serum N-terminal probrain natriuretic peptide (NT-proBNP) concentration, and diastolic functional class and an increase of the ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic lateral mitral annulus motion (E:Ea Lat). In dogs with DCM, resolution of CHF was associated with a decrease in respiratory rate and serum NT-proBNP concentration and significant changes in 7 Doppler echocardiographic variables, including a decrease of E:Ea Lat and the ratio of peak velocity of early diastolic transmitral flow to isovolumic relaxation time. Only respiratory rate predicted the presence of CHF at examination 2 with high accuracy. CONCLUSIONS AND CLINICAL RELEVANCE: Resolution of CHF was associated with predictable changes in respiratory rate, serum NT-proBNP concentration, and selected Doppler echocardiographic variables in dogs with DCM and MVD. Home monitoring of respiratory rate was simple and was the most useful in the assessment of successful treatment of CHF.
Authors: Michelle N Rohrbaugh; Karsten E Schober; Jaylyn D Rhinehart; John D Bonagura; Amy Habing; Vedat Yildiz Journal: J Vet Intern Med Date: 2020-05-04 Impact factor: 3.333
Authors: A-C Merveille; G Bolen; E Krafft; E Roels; S Gomart; A-L Etienne; C Clercx; K Mc Entee Journal: J Vet Intern Med Date: 2015-09-29 Impact factor: 3.333
Authors: P R Fox; M A Oyama; M J Hezzell; J E Rush; T P Nguyenba; T C DeFrancesco; L B Lehmkuhl; H B Kellihan; B Bulmer; S G Gordon; S M Cunningham; J MacGregor; R L Stepien; B Lefbom; D Adin; K Lamb Journal: J Vet Intern Med Date: 2014-10-10 Impact factor: 3.333
Authors: A Boswood; S G Gordon; J Häggström; G Wess; R L Stepien; M A Oyama; B W Keene; J Bonagura; K A MacDonald; M Patteson; S Smith; P R Fox; K Sanderson; R Woolley; V Szatmári; P Menaut; W M Church; M L O'Sullivan; J-P Jaudon; J-G Kresken; J Rush; K A Barrett; S L Rosenthal; A B Saunders; I Ljungvall; M Deinert; E Bomassi; A H Estrada; M J Fernandez Del Palacio; N S Moise; J A Abbott; Y Fujii; A Spier; M W Luethy; R A Santilli; M Uechi; A Tidholm; C Schummer; P Watson Journal: J Vet Intern Med Date: 2017-12-06 Impact factor: 3.333
Authors: Adrian Boswood; Sonya G Gordon; Jens Häggström; Martin Vanselow; Gerhard Wess; Rebecca L Stepien; Mark A Oyama; Bruce W Keene; John Bonagura; Kristin A MacDonald; Mark Patteson; Sarah Smith; Philip R Fox; Karen Sanderson; Richard Woolley; Viktor Szatmári; Pierre Menaut; Whitney M Church; M Lynne O'Sullivan; Jean-Philippe Jaudon; Jan-Gerd Kresken; John Rush; Kirstie A Barrett; Steven L Rosenthal; Ashley B Saunders; Ingrid Ljungvall; Michael Deinert; Eric Bomassi; Amara H Estrada; Maria J Fernandez Del Palacio; N Sydney Moise; Jonathan A Abbott; Yoko Fujii; Alan Spier; Michael W Luethy; Roberto A Santilli; Masami Uechi; Anna Tidholm; Christoph Schummer; Philip Watson Journal: J Vet Intern Med Date: 2020-03-22 Impact factor: 3.333
Authors: Shane D Murphy; Jessica L Ward; Austin K Viall; Melissa A Tropf; Rebecca L Walton; Jennifer L Fowler; Wendy A Ware; Teresa C DeFrancesco Journal: J Vet Intern Med Date: 2020-12-03 Impact factor: 3.175