| Literature DB >> 21837794 |
Manola Comar1, Daniela Bonifacio, Fabrizio Zanconati, Michela Di Napoli, Erica Isidoro, Fernanda Martini, Lucio Torelli, Mauro Tognon.
Abstract
High- and low-grade cervical lesions were analyzed for the presence of polyomavirus (PYV) and human papillomavirus (HPV) sequences. In precancerous cervical lesions, the overall prevalence of PYV sequences was 44% (41/93). Specifically, among the PYV-positive samples, 83% (34/41) tested positive for BK polyomavirus (BKV) sequences, whereas 17% (7/41) were positive for JC-virus. None of the samples were positive for simian virus 40. The presence of BKV DNA in high-grade squamous intraepithelial lesions was confirmed by in situ PCR. BKV sequences were detected more frequently in high-grade squamous intraepithelial lesions, together with the genotype HPV-16. The association of BKV with precancerous cervical lesions suggests that this polyomavirus participates with HPV-16 in the cell transformation process. Alternatively, BKV might multiply better in HPV-16-positive cells from precancerous cervical lesions than in HPV-16-negative cells.Entities:
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Year: 2011 PMID： 21837794 DOI： 10.1002/jmv.22184
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327