PURPOSE: The aim of this study was to determine which clinicopathological factors influenced the long-term survival after potentially curative resection of patients with colon cancer having fewer than 12 retrieved lymph nodes. METHODS: Prospective data were collected from 179 patients who had fewer than 12 resected lymph nodes after curative resection for stages I-III colon cancer. The oncological outcomes and the risk factors for recurrence were analyzed, focusing on lymph node ratio (LNR). RESULTS: The median number of harvested lymph nodes was 7 (range, 1-11). The LNR was associated significantly with T category and lymphovascular invasion. Multivariate analysis revealed that tumor diameter (P = 0.006), perineural invasion (P = 0.043), LNR (P = 0.002), and preoperative carcinoembryonic antigen (CEA) level (P = 0.013) were the independent predictors for 5-year disease-free survival; T category (P = 0.032), postoperative chemotherapy (P = 0.001), LNR (P = 0.007), and preoperative CEA level (P = 0.023) were the independent predictors for 5-year overall survival. CONCLUSIONS: The LNR and preoperative CEA level may be reliable predictors of recurrence and survival after curative surgery in patients with colon cancer who have less than 12 lymph nodes examined.
PURPOSE: The aim of this study was to determine which clinicopathological factors influenced the long-term survival after potentially curative resection of patients with colon cancer having fewer than 12 retrieved lymph nodes. METHODS: Prospective data were collected from 179 patients who had fewer than 12 resected lymph nodes after curative resection for stages I-III colon cancer. The oncological outcomes and the risk factors for recurrence were analyzed, focusing on lymph node ratio (LNR). RESULTS: The median number of harvested lymph nodes was 7 (range, 1-11). The LNR was associated significantly with T category and lymphovascular invasion. Multivariate analysis revealed that tumor diameter (P = 0.006), perineural invasion (P = 0.043), LNR (P = 0.002), and preoperative carcinoembryonic antigen (CEA) level (P = 0.013) were the independent predictors for 5-year disease-free survival; T category (P = 0.032), postoperative chemotherapy (P = 0.001), LNR (P = 0.007), and preoperative CEA level (P = 0.023) were the independent predictors for 5-year overall survival. CONCLUSIONS: The LNR and preoperative CEA level may be reliable predictors of recurrence and survival after curative surgery in patients with colon cancer who have less than 12 lymph nodes examined.
Authors: Ali Ahmad; Jeffrey Reha; Abdul Saied; N Joseph Espat; Ponnandai Somasundar; Steven C Katz Journal: Hepatobiliary Surg Nutr Date: 2017-06 Impact factor: 7.293
Authors: Ji Hoon Kang; Soo Young Lee; Chang Hyun Kim; Hyeong Rok Kim; Han Deok Kwak; Jae Kyun Ju; Young Jin Kim Journal: Ann Surg Treat Res Date: 2018-02-28 Impact factor: 1.859