BACKGROUND: Two genome-wide association studies on gastric cancer showed a previously unknown gastric cancer susceptible locus in PLCE1 at 10q23. We hypothesized that the single nucleotide polymorphism (SNP) rs2274223 A/G is associated with the survival rate of gastric cancer. METHODS: We genotyped the above SNP in 940 gastric cancer patients to investigate the association between the polymorphism and gastric cancer survival by the TaqMan method. RESULTS: We found that patients carrying PLCE1 rs2274223 AA genotype survived for a significantly shorter time than those carrying the AG and GG genotypes (log-rank P = 0.046). This significance was enhanced in the dominant model (AA vs. AG/GG, log-rank P = 0.014). Multivariate Cox regression analyses showed that the AG/GG genotypes were associated with a significantly decreased risk of death from gastric cancer [adjusted hazard ratio (HR) = 0.79, 95% confidence interval (CI) = 0.65-0.95]. Most of stratification analysis did not find an enhanced association between the same genotype and prognosis, except for patients with TNM stage III disease (HR = 0.63, 95% CI = 0.48-0.83). CONCLUSION: Our findings showed that the PLCE1 SNP rs2274223 was associated with significantly improved gastric cancer survival in a Chinese population. Further functional studies are needed to validate our results.
BACKGROUND: Two genome-wide association studies on gastric cancer showed a previously unknown gastric cancer susceptible locus in PLCE1 at 10q23. We hypothesized that the single nucleotide polymorphism (SNP) rs2274223 A/G is associated with the survival rate of gastric cancer. METHODS: We genotyped the above SNP in 940 gastric cancerpatients to investigate the association between the polymorphism and gastric cancer survival by the TaqMan method. RESULTS: We found that patients carrying PLCE1rs2274223 AA genotype survived for a significantly shorter time than those carrying the AG and GG genotypes (log-rank P = 0.046). This significance was enhanced in the dominant model (AA vs. AG/GG, log-rank P = 0.014). Multivariate Cox regression analyses showed that the AG/GG genotypes were associated with a significantly decreased risk of death from gastric cancer [adjusted hazard ratio (HR) = 0.79, 95% confidence interval (CI) = 0.65-0.95]. Most of stratification analysis did not find an enhanced association between the same genotype and prognosis, except for patients with TNM stage III disease (HR = 0.63, 95% CI = 0.48-0.83). CONCLUSION: Our findings showed that the PLCE1 SNP rs2274223 was associated with significantly improved gastric cancer survival in a Chinese population. Further functional studies are needed to validate our results.
Authors: Grant G Kelley; Katherine A Kaproth-Joslin; Sarah E Reks; Alan V Smrcka; Richard J H Wojcikiewicz Journal: J Biol Chem Date: 2005-11-28 Impact factor: 5.157
Authors: Christian C Abnet; Neal D Freedman; Nan Hu; Zhaoming Wang; Kai Yu; Xiao-Ou Shu; Jian-Min Yuan; Wei Zheng; Sanford M Dawsey; Linda M Dong; Maxwell P Lee; Ti Ding; You-Lin Qiao; Yu-Tang Gao; Woon-Puay Koh; Yong-Bing Xiang; Ze-Zhong Tang; Jin-Hu Fan; Chaoyu Wang; William Wheeler; Mitchell H Gail; Meredith Yeager; Jeff Yuenger; Amy Hutchinson; Kevin B Jacobs; Carol A Giffen; Laurie Burdett; Joseph F Fraumeni; Margaret A Tucker; Wong-Ho Chow; Alisa M Goldstein; Stephen J Chanock; Philip R Taylor Journal: Nat Genet Date: 2010-08-22 Impact factor: 38.330
Authors: Andrew J Palmer; Paul Lochhead; Georgina L Hold; Charles S Rabkin; Wong-Ho Chow; Jolanta Lissowska; Thomas L Vaughan; Susan Berry; Marilie Gammon; Harvey Risch; Emad M El-Omar Journal: Eur J Cancer Prev Date: 2012-11 Impact factor: 2.497