Literature DB >> 21837389

Synthesis of 1,5-benzothiazepine derivatives bearing 2-phenoxy-quinoline moiety via 1,3-diplolar cycloaddition reaction.

Zhi-Qiang Dong1, Fang-Ming Liu, Feng Xu, Zai-Liang Yuan.   

Abstract

A series of 1,5-benzothiazepine derivatives were synthesized by the reaction of 1,5-benzothiazepine containing 2-phenoxy-quinoline with benzohydroximinoyl chlorides and hydrazonoyl chlorides at room temperature. The structures of these novel compounds were confirmed by spectrum, elemental, and X-ray crystallographic analysis.

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Year:  2011        PMID： 21837389     DOI： 10.1007/s11030-011-9328-z

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  15 in total

1.  Structural optimization of azadipeptide nitriles strongly increases association rates and allows the development of selective cathepsin inhibitors.

Authors:  Maxim Frizler; Friederike Lohr; Norbert Furtmann; Julia Kläs; Michael Gütschow
Journal:  J Med Chem       Date:  2010-12-03       Impact factor: 7.446

2.  Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.

Authors:  H J Wadsworth; S M Jenkins; B S Orlek; F Cassidy; M S Clark; F Brown; G J Riley; D Graves; J Hawkins; C B Naylor
Journal:  J Med Chem       Date:  1992-04-03       Impact factor: 7.446

3.  Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents.

Authors:  C W Wright; J Addae-Kyereme; A G Breen; J E Brown; M F Cox; S L Croft; Y Gökçek; H Kendrick; R M Phillips; P L Pollet
Journal:  J Med Chem       Date:  2001-09-13       Impact factor: 7.446

4.  Synthesis and antibacterial evaluation of certain quinolone derivatives.

Authors:  Y L Chen; K C Fang; J Y Sheu; S L Hsu; C C Tzeng
Journal:  J Med Chem       Date:  2001-07-05       Impact factor: 7.446

5.  Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems.

Authors:  Takeshi Sakamoto; Matthew D Cullen; Tracy L Hartman; Karen M Watson; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Journal:  J Med Chem       Date:  2007-06-19       Impact factor: 7.446

6.  Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents.

Authors:  Han-Zhong Zhang; Shailaja Kasibhatla; Jared Kuemmerle; William Kemnitzer; Kristin Ollis-Mason; Ling Qiu; Candace Crogan-Grundy; Ben Tseng; John Drewe; Sui Xiong Cai
Journal:  J Med Chem       Date:  2005-08-11       Impact factor: 7.446

7.  Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents.

Authors:  W K Anderson; A N Jones
Journal:  J Med Chem       Date:  1984-12       Impact factor: 7.446

8.  Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: potential therapeutics for type II diabetes.

Authors:  Yazhong Pei; Michael J Lilly; David J Owen; Lawrence J D'Souza; Xiao-Qing Tang; Jinghua Yu; Ramina Nazarbaghi; Andrew Hunter; Christen M Anderson; Susan Glasco; Nicholas J Ede; Ian W James; Uday Maitra; S Chandrasekaran; Walter H Moos; Soumitra S Ghosh
Journal:  J Org Chem       Date:  2003-01-10       Impact factor: 4.354

Review 9.  1,5-Benzothiazepine, a versatile pharmacophore: a review.

Authors:  Jitender B Bariwal; Kuldip D Upadhyay; Atul T Manvar; Jalpa C Trivedi; Jyoti S Singh; Kishor S Jain; Anamik K Shah
Journal:  Eur J Med Chem       Date:  2008-06-06       Impact factor: 6.514

10.  Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists.

Authors:  Daniela Catarzi; Vittoria Colotta; Flavia Varano; Francesca Romana Calabri; Guido Filacchioni; Alessandro Galli; Chiara Costagli; Vincenzo Carlà
Journal:  J Med Chem       Date:  2004-01-01       Impact factor: 7.446
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