BACKGROUND AND PURPOSE: Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians. METHODS: A survey was conducted of a total of 13 129 men and 22 528 women aged 40 to 69 years at baseline. During the median 12.0-year follow-up, there were 526 incidences of ischemic strokes (259 lacunar infarctions, 91 large-artery occlusive, and 140 embolic infarctions). RESULTS: The risk of ischemic stroke for both sexes was approximately 2 to 4 times higher for diabetic subjects than for those with normal glucose levels. Significant excess risks of lacunar and embolic infarction for both sexes and of large-artery occlusive infarctions for women were also observed in diabetic subjects. Diabetes mellitus was not associated with risk of intraparenchymal or subarachnoid hemorrhage for either sex. CONCLUSIONS: Diabetes mellitus is a significant risk factor for ischemic stroke and all subtypes of ischemic stroke for middle-aged Japanese.
BACKGROUND AND PURPOSE: Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians. METHODS: A survey was conducted of a total of 13 129 men and 22 528 women aged 40 to 69 years at baseline. During the median 12.0-year follow-up, there were 526 incidences of ischemic strokes (259 lacunar infarctions, 91 large-artery occlusive, and 140 embolic infarctions). RESULTS: The risk of ischemic stroke for both sexes was approximately 2 to 4 times higher for diabetic subjects than for those with normal glucose levels. Significant excess risks of lacunar and embolic infarction for both sexes and of large-artery occlusive infarctions for women were also observed in diabetic subjects. Diabetes mellitus was not associated with risk of intraparenchymal or subarachnoid hemorrhage for either sex. CONCLUSIONS:Diabetes mellitus is a significant risk factor for ischemic stroke and all subtypes of ischemic stroke for middle-aged Japanese.
Authors: Tomofumi Nishikawa; T Okamura; A Shima; Y Kawatsu; D Sugiyama; A Kadota; A Morimoto; Y Tatsumi; K Godai; N Miyamatsu Journal: Diabetol Int Date: 2015-11-18
Authors: Antti E Lindgren; Mitja I Kurki; Annamaija Riihinen; Timo Koivisto; Antti Ronkainen; Jaakko Rinne; Juha Hernesniemi; Johan G Eriksson; Juha E Jääskeläinen; Mikael von und zu Fraunberg Journal: Diabetes Care Date: 2013-03-27 Impact factor: 19.112