BACKGROUND: Data from population studies using ankle-brachial index (ABI) measurement to screen patients for peripheral arterial disease (PAD) demonstrate that most patients with PAD have no symptoms or atypical symptoms besides classical intermittent claudication. We aimed at comparing health-related quality of life and ABI in a cohort of cardiovascular risk persons in a general population. METHODS: SF-36 questionnaire was completed and ABI measured from 915 individuals aged 45-70 years with hypertension, metabolic syndrome, pre-diabetes, newly detected diabetes, body mass index ≥ 30 kg/m(2), or a 10-year risk of cardiovascular disease death of 5% or more according to the Systematic Coronary Risk Evaluation (SCORE) system. None of the subjects had symptoms of intermittent claudication. RESULTS: The prevalence of PAD (defined as ABI ≤ 0.90) and borderline PAD (defined as ABI 0.91-1.00) were 5% (95% CI 4-7%) and 20% (95% CI 18-23%), respectively. Patients with PAD had significantly lower quality of life dimension scores for physical functioning, role-physical, general health, and vitality than subjects with normal ABI. Among those with borderline PAD, quality of life was reduced on the general health perception compared to subjects with normal ABI. CONCLUSION: Health-related quality of life of individuals with asymptomatic or atypical PAD or borderline PAD is worse than that of individuals with normal ABI. The level of ABI is independently related to physical functioning.
BACKGROUND: Data from population studies using ankle-brachial index (ABI) measurement to screen patients for peripheral arterial disease (PAD) demonstrate that most patients with PAD have no symptoms or atypical symptoms besides classical intermittent claudication. We aimed at comparing health-related quality of life and ABI in a cohort of cardiovascular risk persons in a general population. METHODS: SF-36 questionnaire was completed and ABI measured from 915 individuals aged 45-70 years with hypertension, metabolic syndrome, pre-diabetes, newly detected diabetes, body mass index ≥ 30 kg/m(2), or a 10-year risk of cardiovascular disease death of 5% or more according to the Systematic Coronary Risk Evaluation (SCORE) system. None of the subjects had symptoms of intermittent claudication. RESULTS: The prevalence of PAD (defined as ABI ≤ 0.90) and borderline PAD (defined as ABI 0.91-1.00) were 5% (95% CI 4-7%) and 20% (95% CI 18-23%), respectively. Patients with PAD had significantly lower quality of life dimension scores for physical functioning, role-physical, general health, and vitality than subjects with normal ABI. Among those with borderline PAD, quality of life was reduced on the general health perception compared to subjects with normal ABI. CONCLUSION: Health-related quality of life of individuals with asymptomatic or atypical PAD or borderline PAD is worse than that of individuals with normal ABI. The level of ABI is independently related to physical functioning.
Authors: Christina L Wassel; Matthew A Allison; Joachim H Ix; Dena E Rifkin; Nketi I Forbang; Julie O Denenberg; Michael H Criqui Journal: J Vasc Surg Date: 2016-04-29 Impact factor: 4.268
Authors: Luis García-Ortiz; José I Recio-Rodríguez; Sara Mora-Simón; John Guillaumet; Ruth Martí; Cristina Agudo-Conde; Emiliano Rodriguez-Sanchez; Jose A Maderuelo-Fernandez; Rafel Ramos-Blanes; Manuel A Gómez-Marcos Journal: BMC Cardiovasc Disord Date: 2016-05-12 Impact factor: 2.298
Authors: Aozhou Wu; Josef Coresh; Elizabeth Selvin; Hirofumi Tanaka; Gerardo Heiss; Alan T Hirsch; Bernard G Jaar; Kunihiro Matsushita Journal: J Am Heart Assoc Date: 2017-01-20 Impact factor: 5.501
Authors: Christina L Wassel; Alicia M Ellis; Natalie C Suder; Emma Barinas-Mitchell; Dena E Rifkin; Nketi I Forbang; Julie O Denenberg; Antoinette M Marasco; Belinda J McQuaide; Nancy S Jenny; Matthew A Allison; Joachim H Ix; Michael H Criqui Journal: J Am Heart Assoc Date: 2017-07-20 Impact factor: 5.501