OBJECTIVE: To evaluate pregnancy outcome following late amniocentesis (>24 weeks of gestation). STUDY DESIGN: A retrospective cohort of all women with singleton pregnancy that underwent late amniocentesis in one tertiary center. RESULTS: Pregnancy outcome was validated in 168 women who underwent late amniocentesis. Overall, for the all study group the mean gestational age for amniocentesis was 31.6 ± 2.3 weeks and the mean gestational age at delivery was 38.1 ± 2. Indications for late amniocentesis included abnormal ultrasonographic findings (n = 120), suspected intrauterine infection (n = 23), advanced maternal age (n = 13), abnormal first or second trimester biochemical markers (n = 8) and others. The overall rate of spontaneous preterm delivery (<37 weeks) was 8% (13/168) with mean gestational age at delivery of 34.7 ± 1.3. In only five cases (3%), delivery occurred ≤ 34 weeks of gestation. In one case (0.60%) of amniocentesis performed at 32 weeks of gestation, delivery occurred within 48 hours and in other four cases (2.40%) delivery occurred within 10 days. When amniocentesis was performed due to ultrasonographic findings to rule out chromosomal abnormalities (n = 117/182), abnormal karyotype was found only in three cases. CONCLUSIONS: The risk of significant prematurity following late amniocentesis is low. This information is important when counseling patients considering performing one.
OBJECTIVE: To evaluate pregnancy outcome following late amniocentesis (>24 weeks of gestation). STUDY DESIGN: A retrospective cohort of all women with singleton pregnancy that underwent late amniocentesis in one tertiary center. RESULTS: Pregnancy outcome was validated in 168 women who underwent late amniocentesis. Overall, for the all study group the mean gestational age for amniocentesis was 31.6 ± 2.3 weeks and the mean gestational age at delivery was 38.1 ± 2. Indications for late amniocentesis included abnormal ultrasonographic findings (n = 120), suspected intrauterine infection (n = 23), advanced maternal age (n = 13), abnormal first or second trimester biochemical markers (n = 8) and others. The overall rate of spontaneous preterm delivery (<37 weeks) was 8% (13/168) with mean gestational age at delivery of 34.7 ± 1.3. In only five cases (3%), delivery occurred ≤ 34 weeks of gestation. In one case (0.60%) of amniocentesis performed at 32 weeks of gestation, delivery occurred within 48 hours and in other four cases (2.40%) delivery occurred within 10 days. When amniocentesis was performed due to ultrasonographic findings to rule out chromosomal abnormalities (n = 117/182), abnormal karyotype was found only in three cases. CONCLUSIONS: The risk of significant prematurity following late amniocentesis is low. This information is important when counseling patients considering performing one.