Literature DB >> 21834097

Azabicyclo[3.1.0]hexane-1-carbohydrazides as potent and selective GHSR1a ligands presenting a specific in vivo behavior.

Fabio Maria Sabbatini1, Sergio Melotto, Giovanni Bernasconi, Steve M Bromidge, Lucilla D'Adamo, Marilisa Rinaldi, Chiara Savoia, Claudia Mundi, Carla Di Francesco, Laura Zonzini, Vivian J A Costantini, Benedetta Perini, Enzo Valerio, Alfonso Pozzan, Elisabetta Perdonà, Filippo Visentini, Mauro Corsi, Romano Di Fabio.   

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Year:  2011        PMID： 21834097     DOI： 10.1002/cmdc.201100285

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  2 in total

1.  Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo.

Authors:  J Kong; J Chuddy; I A Stock; P M Loria; S V Straub; C Vage; K O Cameron; S K Bhattacharya; K Lapham; K F McClure; Y Zhang; V M Jackson
Journal:  Br J Pharmacol       Date:  2016-03-17       Impact factor: 8.739

2.  Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.

Authors:  Samit K Bhattacharya; Kim Andrews; Ramsay Beveridge; Kimberly O Cameron; Chiliu Chen; Matthew Dunn; Dilinie Fernando; Hua Gao; David Hepworth; V Margaret Jackson; Vishal Khot; Jimmy Kong; Rachel E Kosa; Kimberly Lapham; Paula M Loria; Allyn T Londregan; Kim F McClure; Suvi T M Orr; Jigna Patel; Colin Rose; James Saenz; Ingrid A Stock; Gregory Storer; Maria VanVolkenburg; Derek Vrieze; Guoqiang Wang; Jun Xiao; Yingxin Zhang
Journal:  ACS Med Chem Lett       Date:  2014-02-24       Impact factor: 4.345
  2 in total

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