Literature DB >> 21833419

Design, synthesis, and drug solubilising properties of the first folate-calix[4]arene conjugate.

Grazia M L Consoli1, Giuseppe Granata, Corrada Geraci.   

Abstract

The first example of a folate-calix[4]arene conjugate was designed and synthesized via microwave-assisted click chemistry. In PBS medium at physiological pH, the conjugate formed soluble aggregates and showed the capability to improve the water-solubility of a hydrophobic drug model, such as indomethacin.

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Year:  2011        PMID： 21833419     DOI： 10.1039/c1ob06032e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  3 in total

1.  Inclusion Complexes of a New Family of Non-Ionic Amphiphilic Dendrocalix[4]arene and Poorly Water-Soluble Drugs Naproxen and Ibuprofen.

Authors:  Khalid Khan; Syed Lal Badshah; Nasir Ahmad; Haroon Ur Rashid; Yahia Mabkhot
Journal:  Molecules       Date:  2017-05-11       Impact factor: 4.411

2.  Effects of the Calix[4]arene Derivative Compound OTX008 on High Glucose-Stimulated ARPE-19 Cells: Focus on Galectin-1/TGF-β/EMT Pathway.

Authors:  Maria Consiglia Trotta; Francesco Petrillo; Carlo Gesualdo; Settimio Rossi; Alberto Della Corte; Judit Váradi; Ferenc Fenyvesi; Michele D'Amico; Anca Hermenean
Journal:  Molecules       Date:  2022-07-26       Impact factor: 4.927

3.  Expanding the Chemical Space of Biocompatible Fluorophores: Nanohoops in Cells.

Authors:  Brittany M White; Yu Zhao; Taryn E Kawashima; Bruce P Branchaud; Michael D Pluth; Ramesh Jasti
Journal:  ACS Cent Sci       Date:  2018-08-30       Impact factor: 14.553
  3 in total

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