Literature DB >> 21832098

Th1/Th2 cytokine profile in patients coinfected with HIV and Leishmania in Brazil.

Maria Zilma Andrade Rodrigues1, Maria Fernanda Rios Grassi, Sanjay Mehta, Xing-Quan Zhang, Luana Leandro Gois, Robert T Schooley, Roberto Badaro.   

Abstract

To evaluate the effects of HIV on immune responses in cutaneous leishmaniasis (CL), we quantified cytokine levels from plasma and stimulated peripheral blood mononuclear cells (PBMCs) from individuals infected with HIV and/or CL. Gamma interferon (IFN-γ) and interleukin 13 (IL-13) levels and the ratio of IFN-γ to IL-10 produced in response to stimulation with soluble Leishmania antigens were significantly lower in HIV-Leishmania-coinfected patients than in CL-monoinfected patients.

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Year:  2011        PMID： 21832098      PMCID： PMC3187026          DOI： 10.1128/CVI.00076-11

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  29 in total

1.  Mucocutaneous leishmaniasis associated with HIV infection treated successfully with liposomal amphotericin B (AmBisome)

Authors:  V S Amato; A C Nicodemo; J G Amato; M Boulos; V A Neto
Journal:  J Antimicrob Chemother       Date:  2000-08       Impact factor: 5.790

2.  IL-10 and IL-12 are the main regulatory cytokines in visceral leishmaniasis.

Authors:  O Bacellar; A D'oliveira; S Jerônimo; E M Carvalho
Journal:  Cytokine       Date:  2000-08       Impact factor: 3.861

3.  CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.

Authors:  Yasmine Belkaid; Ciriaco A Piccirillo; Susana Mendez; Ethan M Shevach; David L Sacks
Journal:  Nature       Date:  2002-12-05       Impact factor: 49.962

4.  Reconstitution of CD4+ T cell responses in HIV-1 infected individuals initiating highly active antiretroviral therapy (HAART) is associated with renewed interleukin-2 production and responsiveness.

Authors:  G A D Hardy; N Imami; A K Sullivan; A Pires; C T Burton; M R Nelson; B G Gazzard; F M Gotch
Journal:  Clin Exp Immunol       Date:  2003-10       Impact factor: 4.330

5.  Cell mediated immunity in American cutaneous and mucosal leishmaniasis.

Authors:  E M Carvalho; W D Johnson; E Barreto; P D Marsden; J L Costa; S Reed; H Rocha
Journal:  J Immunol       Date:  1985-12       Impact factor: 5.422

Review 6.  Leishmania/HIV co-infection in Brazil: an appraisal.

Authors:  A Rabello; M Orsini; J Disch
Journal:  Ann Trop Med Parasitol       Date:  2003-10

7.  Cytokine patterns in the pathogenesis of human leishmaniasis.

Authors:  C Pirmez; M Yamamura; K Uyemura; M Paes-Oliveira; F Conceição-Silva; R L Modlin
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808

8.  Th2 responses predominate during the early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses.

Authors:  Eliane Bourreau; Jacques Gardon; Roger Pradinaud; Hervé Pascalis; Ghislaine Prévot-Linguet; Amina Kariminia; Launois Pascal
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441

9.  Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

Authors:  E M Carvalho; R Badaró; S G Reed; T C Jones; W D Johnson
Journal:  J Clin Invest       Date:  1985-12       Impact factor: 14.808
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  7 in total

1.  A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection.

Authors:  Luiz H Guimarães; Maíra Saldanha; Taís Menezes; Lis Moreno; Alex Torres; Rúbia Costa; Sara Passos; Roberto Badaró; Sérgio Arruda; Lucas P Carvalho
Journal:  Am J Trop Med Hyg       Date:  2015-10-19       Impact factor: 2.345

2.  Leucocytes and Th-associated Cytokine Profile of HIV-Leishmaniasis Co-Infected Persons Attending Abuja Teaching Hospital, Nigeria.

Authors:  Idris Nasir Abdullahi; Anthony Uchenna Emeribe; Hafeez Aderinsayo Adekola; Habiba Yahaya Muhammad; Abdurrahman El-Fulaty Ahmad; Abubakar Umar Anka; Yusuf Mohammed; Shamsuddeen Haruna; Bamidele Soji Oderinde; Halima Ali Shuwa; Adamu Babayo
Journal:  Eurasian J Med       Date:  2020-10

3.  Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis.

Authors:  Luana Leandro Gois; Sanjay Mehta; Maria Zilma Andrade Rodrigues; Robert T Schooley; Roberto Badaró; Maria Fernanda Rios Grassi
Journal:  Mem Inst Oswaldo Cruz       Date:  2013-10-02       Impact factor: 2.743

4.  Plasma But Not Cerebrospinal Fluid Interleukin 7 and Interleukin 5 Levels Pre-Antiretroviral Therapy Commencement Predict Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome.

Authors:  Ngomu Akeem Akilimali; Christina C Chang; Daniel M Muema; Tarylee Reddy; Mahomed-Yunus S Moosa; Sharon R Lewin; Martyn A French; Thumbi Ndung'u
Journal:  Clin Infect Dis       Date:  2017-10-16       Impact factor: 9.079

Review 5.  PKDL and other dermal lesions in HIV co-infected patients with Leishmaniasis: review of clinical presentation in relation to immune responses.

Authors:  Eduard E Zijlstra
Journal:  PLoS Negl Trop Dis       Date:  2014-11-20

6.  Immune response to Leishmania antigens in an AIDS patient with mucocutaneous leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome (IRIS): a case report.

Authors:  Luana Gois; Roberto Badaró; Robert Schooley; Maria Fernanda Rios Grassi
Journal:  BMC Infect Dis       Date:  2015-02-03       Impact factor: 3.090

Review 7.  The Binomial Parasite-Host Immunity in the Healing Process and in Reactivation of Human Tegumentary Leishmaniasis.

Authors:  Fatima Conceição-Silva; Jessica Leite-Silva; Fernanda N Morgado
Journal:  Front Microbiol       Date:  2018-06-19       Impact factor: 5.640
  7 in total

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