| Literature DB >> 21831545 |
Dhwanishiva Vasani1, David Y Josephson, Courtney Carmichael, Oliver Sartor, Sumanta Kumar Pal.
Abstract
Within the past two years, three agents have garnered approval from the US FDA for the specific treatment of metastatic castration resistant prostate cancer (mCRPC) - (1) abiraterone, (2) cabazitaxel and (3) sipuleucel-T. In separate phase III studies, each agent led to an improvement in overall survival (OS) of 2-4 months over a suitable comparator. With these costly therapies all having potential application in the patient with mCRPC, multiple entities (industry, government, and the general public) must strategize to determine how the cost burden of these agents can be balanced with the potential gains for the individual patient. Herein, we provide a framework with which to approach this dilemma.Entities:
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Year: 2011 PMID： 21831545 PMCID： PMC3253818 DOI： 10.1016/j.maturitas.2011.07.018
Source DB: PubMed Journal: Maturitas ISSN： 0378-5122 Impact factor: 4.342