OBJECTIVES: To review neuroimaging intermediate phenotypes of MDD and their relation to genetic risk variants. METHODS: A systematic literature search of peer-reviewed English language articels using PubMed ( www.pubmed.org ) was performed. RESULTS: Comprehensive evidence on the influence of serotonergic genes (SLC6A4, HTR1A, MAOA, TPH2) and BDNF on the following neural intermediate phenotypes is displayed: amygdala reactivity, coupling of amygdala-anterior cingulate cortex (ACC) activity, ACC volume, hippocampal volume and serotonin receptor 1A (5-HT1A) binding potential (BP). CONCLUSIONS: Intermediate phenotypes may bridge the gap between genotype and phenotype by reducing the impreciseness of psychiatric phenotypes and yield more insights into the underlying biology.
OBJECTIVES: To review neuroimaging intermediate phenotypes of MDD and their relation to genetic risk variants. METHODS: A systematic literature search of peer-reviewed English language articels using PubMed ( www.pubmed.org ) was performed. RESULTS: Comprehensive evidence on the influence of serotonergic genes (SLC6A4, HTR1A, MAOA, TPH2) and BDNF on the following neural intermediate phenotypes is displayed: amygdala reactivity, coupling of amygdala-anterior cingulate cortex (ACC) activity, ACC volume, hippocampal volume and serotonin receptor 1A (5-HT1A) binding potential (BP). CONCLUSIONS: Intermediate phenotypes may bridge the gap between genotype and phenotype by reducing the impreciseness of psychiatric phenotypes and yield more insights into the underlying biology.
Authors: H Welper; A Aller; V Guttenthaler; S Höfels; L Lennertz; U Pfeiffer; S G Schwab; A Zobel Journal: Nervenarzt Date: 2014-03 Impact factor: 1.214
Authors: Jeanne E Savage; Chelsea Sawyers; Roxann Roberson-Nay; John M Hettema Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2016-05-19 Impact factor: 3.568
Authors: Saskia Woudstra; Marie-José van Tol; Zoltán Bochdanovits; Nic J van der Wee; Frans G Zitman; Mark A van Buchem; Esther M Opmeer; André Aleman; Brenda W Penninx; Dick J Veltman; Witte J Hoogendijk Journal: PLoS One Date: 2013-04-19 Impact factor: 3.240