| Literature DB >> 21830769 |
Cheol Am Hong1, Soo Hyeon Lee, Jee Seon Kim, Ji Won Park, Ki Hyun Bae, Hyejung Mok, Tae Gwan Park, Haeshin Lee.
Abstract
The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity.Entities:
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Year: 2011 PMID： 21830769 DOI： 10.1021/ja2056984
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419