Literature DB >> 21829824

Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ.

Matthew A DeSieno1, Wilfred A van der Donk, Huimin Zhao.   

Abstract

The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21829824      PMCID： PMC4091617          DOI： 10.1039/c1cc13597j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  20 in total

1.  Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity.

Authors:  A Reichenberg; J Wiesner; C Weidemeyer; E Dreiseidler; S Sanderbrand; B Altincicek; E Beck; M Schlitzer; H Jomaa
Journal:  Bioorg Med Chem Lett       Date:  2001-03-26       Impact factor: 2.823

2.  Molecular and Biochemical Characterization of Rat epsilon -N-Trimethyllysine Hydroxylase, the First Enzyme of Carnitine Biosynthesis.

Authors:  F M Vaz; R Ofman; K Westinga; J W Back; R J Wanders
Journal:  J Biol Chem       Date:  2001-06-28       Impact factor: 5.157

3.  Phosphonomycin, a new antibiotic produced by strains of streptomyces.

Authors:  D Hendlin; E O Stapley; M Jackson; H Wallick; A K Miller; F J Wolf; T W Miller; L Chaiet; F M Kahan; E L Foltz; H B Woodruff; J M Mata; S Hernandez; S Mochales
Journal:  Science       Date:  1969-10-03       Impact factor: 47.728

4.  Studies on new phosphonic acid antibiotics. IV. Structure determination of FR-33289, FR-31564 and FR-32863.

Authors:  Y Kuroda; M Okuhara; T Goto; M Okamoto; H Terano; M Kohsaka; H Aoki; H Imanaka
Journal:  J Antibiot (Tokyo)       Date:  1980-01       Impact factor: 2.649

5.  Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli.

Authors:  E Eichhorn; J R van der Ploeg; M A Kertesz; T Leisinger
Journal:  J Biol Chem       Date:  1997-09-12       Impact factor: 5.157

6.  A phosphonate-induced gene which promotes Penicillium-mediated bioconversion of cis-propenylphosphonic acid to fosfomycin.

Authors:  M Watanabe; N Sumida; S Murakami; H Anzai; C J Thompson; Y Tateno; T Murakami
Journal:  Appl Environ Microbiol       Date:  1999-03       Impact factor: 4.792

7.  Pharmacokinetics and metabolism of fosmidomycin, a new phosphonic acid, in rats and dogs.

Authors:  T Tsuchiya; K Ishibashi; M Terakawa; M Nishiyama; N Itoh; H Noguchi
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1982 Jan-Mar       Impact factor: 2.441

8.  Studies on new phosphonic acid antibiotics. III. Isolation and characterization of FR-31564, FR-32863 and FR-33289.

Authors:  M Okuhara; Y Kuroda; T Goto; M Okamoto; H Terano; M Kohsaka; H Aoki; H Imanaka
Journal:  J Antibiot (Tokyo)       Date:  1980-01       Impact factor: 2.649

Review 9.  FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes.

Authors:  Robert P Hausinger
Journal:  Crit Rev Biochem Mol Biol       Date:  2004 Jan-Feb       Impact factor: 8.250

10.  Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity.

Authors:  Regina Ortmann; Jochen Wiesner; Armin Reichenberg; Dajana Henschker; Ewald Beck; Hassan Jomaa; Martin Schlitzer
Journal:  Bioorg Med Chem Lett       Date:  2003-07-07       Impact factor: 2.823
View more
  3 in total

1.  MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.

Authors:  Xu Wang; Rachel L Edwards; Haley Ball; Claire Johnson; Amanda Haymond; Misgina Girma; Michelle Manikkam; Robert C Brothers; Kyle T McKay; Stacy D Arnett; Damon M Osbourn; Sophie Alvarez; Helena I Boshoff; Marvin J Meyers; Robin D Couch; Audrey R Odom John; Cynthia S Dowd
Journal:  J Med Chem       Date:  2018-09-24       Impact factor: 7.446

2.  Structural analysis of a phosphonate hydroxylase with an access tunnel at the back of the active site.

Authors:  Changqing Li; Muhammad Junaid; Eman Abdullah Almuqri; Shiguang Hao; Houjin Zhang
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2016-04-22       Impact factor: 1.056

3.  Cyanohydrin phosphonate natural product from Streptomyces regensis.

Authors:  Joel P Cioni; James R Doroghazi; Kou-San Ju; Xiaomin Yu; Bradley S Evans; Jaeheon Lee; William W Metcalf
Journal:  J Nat Prod       Date:  2014-01-17       Impact factor: 4.050
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.