Andrew Davenport1, Rabya Hussain Sayed, Stanley Fan. 1. UCL Center for Nephrology, University College London Medical School, Royal Free Campus, Rowland Hill Street, London, UK. andrewdavenport@nhs.net
Abstract
BACKGROUND AND OBJECTIVES: Residual renal function (RRF) is important for peritoneal dialysis (PD) technique failure and patient survival. Reduction in extracellular water (ECW) has been reported to reduce urine output. We audited volume status and RRF to determine whether ECW was linked to urinary output. METHODS: We retrospectively audited PD patients who had RRF and multiple frequency bioimpedance spectroscopy assessments. RESULTS: 550 patients were studied. Urine output was lower in males (p = 0.021), non-Caucasoids (p = 0.04), those prescribed antihypertensives (p < 0.001), and greater glucose dialysate usage (p < 0.001). Urine output was negatively associated with dialysis vintage (F = 40.7, β -0.627, p < 0.001), and ECW (F = 33.7, β -0.177, p < 0.001) and positively associated with intracellular volume (F = 34.6, β 0.11, p < 0.001). CONCLUSIONS: RRF is important for successful PD, and ECW volume expansion may lead to better preservation of RRF in PD patients compared to haemodialysis. However, in our retrospective cross-sectional study, ECW expansion was associated with reduced urine output.
BACKGROUND AND OBJECTIVES: Residual renal function (RRF) is important for peritoneal dialysis (PD) technique failure and patient survival. Reduction in extracellular water (ECW) has been reported to reduce urine output. We audited volume status and RRF to determine whether ECW was linked to urinary output. METHODS: We retrospectively audited PDpatients who had RRF and multiple frequency bioimpedance spectroscopy assessments. RESULTS: 550 patients were studied. Urine output was lower in males (p = 0.021), non-Caucasoids (p = 0.04), those prescribed antihypertensives (p < 0.001), and greater glucose dialysate usage (p < 0.001). Urine output was negatively associated with dialysis vintage (F = 40.7, β -0.627, p < 0.001), and ECW (F = 33.7, β -0.177, p < 0.001) and positively associated with intracellular volume (F = 34.6, β 0.11, p < 0.001). CONCLUSIONS: RRF is important for successful PD, and ECW volume expansion may lead to better preservation of RRF in PDpatients compared to haemodialysis. However, in our retrospective cross-sectional study, ECW expansion was associated with reduced urine output.
Authors: Rachel M Kruzan; Charles A Herzog; Aozhou Wu; Yingying Sang; Rulan S Parekh; Kunihiro Matsushita; Seungyoung Hwang; Alan Cheng; Josef Coresh; Neil R Powe; Tariq Shafi Journal: BMC Nephrol Date: 2016-02-20 Impact factor: 2.388
Authors: John T Daugirdas; Tom Greene; Michael V Rocco; George A Kaysen; Thomas A Depner; Nathan W Levin; Glenn M Chertow; Daniel B Ornt; Jochen G Raimann; Brett Larive; Alan S Kliger Journal: Kidney Int Date: 2013-01-23 Impact factor: 10.612