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Literature DB >> 21828240

B-Myb, cancer, senescence, and microRNAs.

Abstract

The transcription factor B-Myb plays a critical role in regulating gene expression and is implicated in controlling carcinogenesis and cellular senescence. Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting directly on the B-Myb promoter. Recently, we found that microRNAs also control the abundance of B-Myb mRNA during senescence, adding another level of complexity to B-Myb regulation. This review focuses on the importance of B-Myb in cancer and senescence, with an emphasis on the regulation of B-Myb expression and activity.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 21828240 PMCID： PMC3156249 DOI： 10.1158/0008-5472.CAN-11-1044

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

44 in total

1. Target gene specificity of E2F and pocket protein family members in living cells.

Authors: J Wells; K E Boyd; C J Fry; S M Bartley; P J Farnham
Journal: Mol Cell Biol Date: 2000-08 Impact factor: 4.272

2. Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft.

Authors: Anat Bar-Shira; Jehonathan H Pinthus; Uri Rozovsky; Myriam Goldstein; William R Sellers; Yuval Yaron; Zelig Eshhar; Avi Orr-Urtreger
Journal: Cancer Res Date: 2002-12-01 Impact factor: 12.701

3. miR-29 and miR-30 regulate B-Myb expression during cellular senescence.

Authors: Ivan Martinez; Demian Cazalla; Laura L Almstead; Joan A Steitz; Daniel DiMaio
Journal: Proc Natl Acad Sci U S A Date: 2010-12-27 Impact factor: 11.205

4. Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB.

Authors: M Cervellera; G Raschella; G Santilli; B Tanno; A Ventura; C Mancini; C Sevignani; B Calabretta; A Sala
Journal: J Biol Chem Date: 2000-07-14 Impact factor: 5.157

5. Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway.

Authors: S Charrasse; I Carena; V Brondani; K H Klempnauer; S Ferrari
Journal: Oncogene Date: 2000-06-15 Impact factor: 9.867

6. Effects of B-Myb on gene transcription: phosphorylation-dependent activity ans acetylation by p300.

Authors: Lance R Johnson; Teresa K Johnson; Michelle Desler; Troy A Luster; Tamara Nowling; Robert E Lewis; Angie Rizzino
Journal: J Biol Chem Date: 2001-12-03 Impact factor: 5.157

7. B-myb rescues ras-induced premature senescence, which requires its transactivation domain.

Authors: H Masselink; N Vastenhouw; R Bernards
Journal: Cancer Lett Date: 2001-09-28 Impact factor: 8.679

8. Myb protein specificity: evidence of a context-specific transcription factor code.

Authors: Scott A Ness
Journal: Blood Cells Mol Dis Date: 2003 Sep-Oct Impact factor: 3.039

9. Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells.

Authors: Rosa Anna DeFilippis; Edward C Goodwin; Lingling Wu; Daniel DiMaio
Journal: J Virol Date: 2003-01 Impact factor: 5.103

10. Addiction of MYCN amplified tumours to B-MYB underscores a reciprocal regulatory loop.

Authors: Francesco Gualdrini; Daisy Corvetta; Sandra Cantilena; Olesya Chayka; Barbara Tanno; Giuseppe Raschellà; Arturo Sala
Journal: Oncotarget Date: 2010-08

28 in total

1. Diagnostic value of microRNAs in discriminating malignant thyroid nodules from benign ones on fine-needle aspiration samples.

Authors: Yang Zhang; Qi Zhong; Xiaohong Chen; Jugao Fang; Zhigang Huang
Journal: Tumour Biol Date: 2014-06-19

2. Identification of microRNAs as novel biomarkers for detecting esophageal squamous cell carcinoma in Asians: a meta-analysis.

Authors: Yanying Wang; Qingxiu Wang; Na Zhang; Hong Ma; Yuchun Gu; Hongming Tang; Zengguang Xu; Yong Gao
Journal: Tumour Biol Date: 2014-08-19

3. Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.

Authors: Zhihui Zhou; Yanlin Yin; Qun Chang; Guanqun Sun; Jiahui Lin; Yalei Dai
Journal: Cell Prolif Date: 2016-11-23 Impact factor: 6.831

4. Construction of an integrated gene regulatory network link to stress-related immune system in cattle.

Authors: Elham Behdani; Mohammad Reza Bakhtiarizadeh
Journal: Genetica Date: 2017-08-20 Impact factor: 1.082

5. A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.

Authors: Russell J H Ryan; Jelena Petrovic; Dylan M Rausch; Yeqiao Zhou; Caleb A Lareau; Michael J Kluk; Amanda L Christie; Winston Y Lee; Daniel R Tarjan; Bingqian Guo; Laura K H Donohue; Shawn M Gillespie; Valentina Nardi; Ephraim P Hochberg; Stephen C Blacklow; David M Weinstock; Robert B Faryabi; Bradley E Bernstein; Jon C Aster; Warren S Pear
Journal: Cell Rep Date: 2017-10-17 Impact factor: 9.423

6. DNA microarray and signal transduction analysis in pulmonary artery smooth muscle cells from heritable and idiopathic pulmonary arterial hypertension subjects.

Authors: Jun Yu; Jamie Wilson; Linda Taylor; Peter Polgar
Journal: J Cell Biochem Date: 2015-03 Impact factor: 4.429

10. Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells.

Authors: Swanhild U Meyer; Stefan Krebs; Christian Thirion; Helmut Blum; Sabine Krause; Michael W Pfaffl
Journal: PLoS One Date: 2015-10-08 Impact factor: 3.240