Literature DB >> 21826368

A fluoro analogue of UDP-α-D-glucuronic acid is an inhibitor of UDP-α-D-apiose/UDP-α-D-xylose synthase.

Sei-hyun Choi1, Mark W Ruszczycky, Hua Zhang, Hung-wen Liu.   

Abstract

UDP-2F-glucuronic acid was synthesized and analyzed as a mechanistic probe to investigate the ring contraction step catalyzed by UDP-d-apiose/UDP-d-xylose synthase (AXS).

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Year:  2011        PMID： 21826368     DOI： 10.1039/c1cc13140k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Functional assignment of multiple catabolic pathways for D-apiose.

Authors:  Michael S Carter; Xinshuai Zhang; Hua Huang; Jason T Bouvier; Brian San Francisco; Matthew W Vetting; Nawar Al-Obaidi; Jeffrey B Bonanno; Agnidipta Ghosh; Rémi G Zallot; Harvey M Andersen; Steven C Almo; John A Gerlt
Journal:  Nat Chem Biol       Date:  2018-06-04       Impact factor: 15.040

2.  Analysis of UDP-D-apiose/UDP-D-xylose synthase-catalyzed conversion of UDP-D-apiose phosphonate to UDP-D-xylose phosphonate: implications for a retroaldol-aldol mechanism.

Authors:  Sei-hyun Choi; Steven O Mansoorabadi; Yung-nan Liu; Tun-Cheng Chien; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2012-08-15       Impact factor: 15.419

3.  Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid.

Authors:  Thomas Eixelsberger; Sabine Sykora; Sigrid Egger; Michael Brunsteiner; Kathryn L Kavanagh; Udo Oppermann; Lothar Brecker; Bernd Nidetzky
Journal:  J Biol Chem       Date:  2012-07-18       Impact factor: 5.157

4.  Isotope Probing of the UDP-Apiose/UDP-Xylose Synthase Reaction: Evidence of a Mechanism via a Coupled Oxidation and Aldol Cleavage.

Authors:  Thomas Eixelsberger; Doroteja Horvat; Alexander Gutmann; Hansjörg Weber; Bernd Nidetzky
Journal:  Angew Chem Int Ed Engl       Date:  2017-01-19       Impact factor: 15.336

5.  Deciphering the enzymatic mechanism of sugar ring contraction in UDP-apiose biosynthesis.

Authors:  Simone Savino; Annika J E Borg; Alexander Dennig; Martin Pfeiffer; Francesca de Giorgi; Hansjörg Weber; Kshatresh Dutta Dubey; Carme Rovira; Andrea Mattevi; Bernd Nidetzky
Journal:  Nat Catal       Date:  2019-11-25
  5 in total

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