BACKGROUND: Cognitive dysfunction has a major role in health outcomes for cardiac patients. The association of cognitive dysfunction with heart failure is well established, but the cardiac variables that contribute to cognition are not well understood. OBJECTIVES: To investigate the relationships among age, memory, and left ventricular ejection fraction (EF) in patients with heart failure. DESIGN: Retrospective study. SETTING: Academic medical center. PARTICIPANTS: A total of 207 patients with heart failure underwent neuropsychological assessment of memory on standardized tests. MAIN OUTCOME MEASURES: Patients were grouped by age quartiles, and memory function was compared in those with an EF below 30% vs those with an EF of 30% or higher. RESULTS: Demographic, cognitive, and medical variables having a significant association with a memory composite score were identified in a univariate linear regression analysis. In a multivariate linear model that adjusted for significant covariates, there was a significant interaction between age and EF for memory function. Patients younger than 63 years maintained stable memory function across EF levels, but patients 63 years or older showed a significant decline in memory performance when EF dropped below 30% (P < .02). Post hoc multivariate analysis showed that verbal delayed recall and recognition were the components of memory most affected by low EF. CONCLUSION: The effect of EF on memory differs by age such that older patients with lower EFs have significantly reduced verbal memory function.
BACKGROUND:Cognitive dysfunction has a major role in health outcomes for cardiac patients. The association of cognitive dysfunction with heart failure is well established, but the cardiac variables that contribute to cognition are not well understood. OBJECTIVES: To investigate the relationships among age, memory, and left ventricular ejection fraction (EF) in patients with heart failure. DESIGN: Retrospective study. SETTING: Academic medical center. PARTICIPANTS: A total of 207 patients with heart failure underwent neuropsychological assessment of memory on standardized tests. MAIN OUTCOME MEASURES: Patients were grouped by age quartiles, and memory function was compared in those with an EF below 30% vs those with an EF of 30% or higher. RESULTS: Demographic, cognitive, and medical variables having a significant association with a memory composite score were identified in a univariate linear regression analysis. In a multivariate linear model that adjusted for significant covariates, there was a significant interaction between age and EF for memory function. Patients younger than 63 years maintained stable memory function across EF levels, but patients 63 years or older showed a significant decline in memory performance when EF dropped below 30% (P < .02). Post hoc multivariate analysis showed that verbal delayed recall and recognition were the components of memory most affected by low EF. CONCLUSION: The effect of EF on memory differs by age such that older patients with lower EFs have significantly reduced verbal memory function.
Authors: Marykay A Pavol; Joshua Z Willey; Ying Wei; Melana Yuzefpolskaya; Randolph S Marshall; Philip J Marascalco; Jason Harwood; Ronald M Lazar Journal: Gen Thorac Cardiovasc Surg Date: 2018-05-23
Authors: Peter van Vliet; Behnam Sabayan; Liselotte W Wijsman; Rosalinde K E Poortvliet; Simon P Mooijaart; Wouter de Ruijter; Jacobijn Gussekloo; Anton J M de Craen; R G J Westendorp Journal: Neurology Date: 2014-08-20 Impact factor: 9.910
Authors: Fawzi Abukhalil; Aakash Bodhit; Peter Y Cai; Saeed Ansari; Spandana Thenkabail; Sarah Ganji; Pradeepan Saravanapavan; Chandana Chandra Shekhar; Michael F Waters; Thomas M Beaver; Vishnumurthy Shushrutha Hedna Journal: J Atr Fibrillation Date: 2013-08-31
Authors: Michael L Alosco; Sarah Garcia; Mary Beth Spitznagel; Manfred van Dulmen; Ronald Cohen; Lawrence H Sweet; Richard Josephson; Joel Hughes; Jim Rosneck; John Gunstad Journal: Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Date: 2013-08-01
Authors: Lillian Min; Lauren Mazzurco; Tanya R Gure; Christine T Cigolle; Pearl Lee; Cathie Bloem; Chiao-Li Chan; Matthew A Romano; Brahmajee K Nallamothu; Kenneth M Langa; Richard L Prager; Preeti N Malani Journal: J Surg Res Date: 2014-10-31 Impact factor: 2.192