BACKGROUND: There is increasing evidence that in utero growth has both immediate and far-reaching influence on health. Birth weight and length are used as surrogate measures of in utero growth. However, these measures poorly reflect neonatal adiposity. Air-displacement plethysmography has been validated for the measurement of body fat in the neonatal population. OBJECTIVE: The goal of this study was to show the normal reference values of percentage body fat (%BF) in infants during the first 4 days of life. METHODS: As part of a large population-based birth cohort study, fat mass, fat-free mass, and %BF were measured within the first 4 days of life using air-displacement plethsymography. Infants were grouped into gestational age and gender categories. RESULTS: Of the 786 enrolled infants, fat mass, fat-free mass, and %BF were measured in 743 (94.5%) infants within the first 4 days of life. %BF increased significantly with gestational age. Mean (SD) %BF at 36 to 37⁶/⁷ weeks' gestation was 8.9% (3.5%); at 38 to 39 weeks' gestation, 10.3% (4%); and at 40 to 41⁶/⁷ weeks' gestation, 11.2% (4.3%) (P < .001). Female infants had significantly increased mean (SD) %BF at 38 to 39⁶/⁷ (11.1% [3.9%] vs 9.8% [3.9%]; P = .012) and at 40 to 41⁶/⁷ (12.5% [4.4%] vs 10% [3.9%]; P < .001) weeks' gestation compared with male infants. Gender- and gestational age-specific centiles were calculated, and a normative table was generated for reference. CONCLUSION: %BF at birth is influenced by gestational age and gender. We generated accurate %BF centiles from a large population-based cohort.
BACKGROUND: There is increasing evidence that in utero growth has both immediate and far-reaching influence on health. Birth weight and length are used as surrogate measures of in utero growth. However, these measures poorly reflect neonatal adiposity. Air-displacement plethysmography has been validated for the measurement of body fat in the neonatal population. OBJECTIVE: The goal of this study was to show the normal reference values of percentage body fat (%BF) in infants during the first 4 days of life. METHODS: As part of a large population-based birth cohort study, fat mass, fat-free mass, and %BF were measured within the first 4 days of life using air-displacement plethsymography. Infants were grouped into gestational age and gender categories. RESULTS: Of the 786 enrolled infants, fat mass, fat-free mass, and %BF were measured in 743 (94.5%) infants within the first 4 days of life. %BF increased significantly with gestational age. Mean (SD) %BF at 36 to 37⁶/⁷ weeks' gestation was 8.9% (3.5%); at 38 to 39 weeks' gestation, 10.3% (4%); and at 40 to 41⁶/⁷ weeks' gestation, 11.2% (4.3%) (P < .001). Female infants had significantly increased mean (SD) %BF at 38 to 39⁶/⁷ (11.1% [3.9%] vs 9.8% [3.9%]; P = .012) and at 40 to 41⁶/⁷ (12.5% [4.4%] vs 10% [3.9%]; P < .001) weeks' gestation compared with male infants. Gender- and gestational age-specific centiles were calculated, and a normative table was generated for reference. CONCLUSION: %BF at birth is influenced by gestational age and gender. We generated accurate %BF centiles from a large population-based cohort.
Authors: Sani M Roy; David A Fields; Jonathan A Mitchell; Colin P Hawkes; Andrea Kelly; Gary D Wu; Patricia A DeRusso; Michal A Elovitz; Eileen Ford; Danielle Drigo; Babette S Zemel; Shana E McCormack Journal: J Pediatr Date: 2018-09-26 Impact factor: 4.406
Authors: Sisitha Jayasinghe; Manoja P Herath; Jeffrey M Beckett; Kiran D K Ahuja; Nuala M Byrne; Andrew P Hills Journal: Eur J Clin Nutr Date: 2020-10-14 Impact factor: 4.016
Authors: Jacqueline M Wallace; John S Milne; Raymond P Aitken; Dale A Redmer; Lawrence P Reynolds; Justin S Luther; Graham W Horgan; Clare L Adam Journal: J Mol Endocrinol Date: 2015-04-27 Impact factor: 5.098