Literature DB >> 21824690

Comparative study on antioxidant capacity of flavonoids and their inhibitory effects on oleic acid-induced hepatic steatosis in vitro.

Di Zhang1, Liyang Xie, Gang Jia, Shengbao Cai, Baoping Ji, Yixiang Liu, Wei Wu, Feng Zhou, Aili Wang, Le Chu, Ying Wei, Jia Liu, Fengyi Gao.   

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and its incidence is rising worldwide. We compared the antioxidant capacity of seventeen flavonoids with their inhibitory effects on oleic acid-induced triglyceride (TG) over-accumulation in HepG2 cells. The results showed significant correlations (P < 0.01) between the inhibition of intracellular TG levels and the suppression effects on reactive oxygen species. Nevertheless, the radical-reducing activities of flavonoids assessed by chemical assays (cyclic voltammetry and Folin-Ciocalteu reagent assay) were poorly correlated with their intracellular TG inhibitory effects. The relationships between structural properties of flavonoids and their inhibitory effects on TG over-accumulation were discussed.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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Year:  2011        PMID： 21824690     DOI： 10.1016/j.ejmech.2011.07.031

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  11 in total

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6.  Protective Effects of Five Structurally Diverse Flavonoid Subgroups against Chronic Alcohol-Induced Hepatic Damage in a Mouse Model.

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7.  Antioxidant Capacity of Proteins and Hydrolysates from the Liver of Newborn Piglets, and Their Inhibitory Effects on Steatosis in vitro.

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Journal:  BMC Complement Med Ther       Date:  2020-08-01

Review 10.  Molecular Level Insight Into the Benefit of Myricetin and Dihydromyricetin Uptake in Patients With Alzheimer's Diseases.

Authors:  Miaomiao Liu; Hong Guo; Zhongyuan Li; Chenghua Zhang; Xiaoping Zhang; Qinghua Cui; Jingzhen Tian
Journal:  Front Aging Neurosci       Date:  2020-10-23       Impact factor: 5.750
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