AIMS: To describe the distribution of HOMA-IR levels in a general nondiabetic population and its relationships with metabolic and lifestyles characteristics. METHODS: Cross-sectional study. Data from 2246 nondiabetic adults in a random Spanish population sample, stratified by age and gender, were analyzed. Assessments included a structured interview, physical examination, and blood sampling. Generalized additive models (GAMs) were used to assess the effect of lifestyle habits and clinical and demographic measurements on HOMA-IR. Multivariate GAMs and quantile regression analyses of HOMA-IR were carried out separately in men and women. RESULTS: This study shows refined estimations of HOMA-IR levels by age, body mass index, and waist circumference in men and women. HOMA-IR levels were higher in men (2.06) than women (1.95) (P=0.047). In women, but not men, HOMA-IR and age showed a significant nonlinear association (P=0.006), with increased levels above fifty years of age. We estimated HOMA-IR curves percentile in men and women. CONCLUSIONS: Age- and gender-adjusted HOMA-IR levels are reported in a representative Spanish adult non-diabetic population. There are gender-specific differences, with increased levels in women over fifty years of age that may be related with changes in body fat distribution after menopause.
AIMS: To describe the distribution of HOMA-IR levels in a general nondiabetic population and its relationships with metabolic and lifestyles characteristics. METHODS: Cross-sectional study. Data from 2246 nondiabetic adults in a random Spanish population sample, stratified by age and gender, were analyzed. Assessments included a structured interview, physical examination, and blood sampling. Generalized additive models (GAMs) were used to assess the effect of lifestyle habits and clinical and demographic measurements on HOMA-IR. Multivariate GAMs and quantile regression analyses of HOMA-IR were carried out separately in men and women. RESULTS: This study shows refined estimations of HOMA-IR levels by age, body mass index, and waist circumference in men and women. HOMA-IR levels were higher in men (2.06) than women (1.95) (P=0.047). In women, but not men, HOMA-IR and age showed a significant nonlinear association (P=0.006), with increased levels above fifty years of age. We estimated HOMA-IR curves percentile in men and women. CONCLUSIONS: Age- and gender-adjusted HOMA-IR levels are reported in a representative Spanish adult non-diabetic population. There are gender-specific differences, with increased levels in women over fifty years of age that may be related with changes in body fat distribution after menopause.
Authors: Orly Vardeny; Deepak K Gupta; Brian Claggett; Stuart Burke; Amil Shah; Laura Loehr; Laura Rasmussen-Torvik; Elizabeth Selvin; Patricia P Chang; David Aguilar; Scott D Solomon Journal: JACC Heart Fail Date: 2013-12 Impact factor: 12.035
Authors: Kathy Pan; Rebecca A Nelson; Jean Wactawski-Wende; Delphine J Lee; JoAnn E Manson; Aaron K Aragaki; Joanne E Mortimer; Lawrence S Phillips; Thomas Rohan; Gloria Y F Ho; Nazmus Saquib; Aladdin H Shadyab; Rami Nassir; Jinnie J Rhee; Arti Hurria; Rowan T Chlebowski Journal: J Natl Cancer Inst Date: 2020-02-01 Impact factor: 13.506
Authors: Victoria J Vieira-Potter; Jaume Padilla; Young-Min Park; Rebecca J Welly; Rebecca J Scroggins; Steven L Britton; Lauren G Koch; Nathan T Jenkins; Jacqueline M Crissey; Terese Zidon; E Matthew Morris; Grace M E Meers; John P Thyfault Journal: Am J Physiol Regul Integr Comp Physiol Date: 2015-01-21 Impact factor: 3.619
Authors: Mervat Y Hanafi; Taha M Abdelkhalek; Mohamed I Saad; Moustafa M Saleh; Maha M Haiba; Maher A Kamel Journal: J Physiol Biochem Date: 2016-04-02 Impact factor: 4.158