Literature DB >> 218237

Investigation of the mechanism of decreased sensitivity of the rat seminal vesicle to norepinephrine by lithium.

P D Patel, D S Shah, S R Patel, O D Gulati.   

Abstract

Li+ is reported to reduce sensitivity of alpha-adrenergic receptors to NE. The present investigation was designed to investigate the mechanism of this decreased sensitivity on the rat isolated seminal vesicle. In innervated preparations, 1.35 X 10(-3) M Li+ (i) shifted the concentration-response curves of NE, methoxamine, ACh and BaCl2 to the right and reduced their maximum responses; (ii) antagonized the leftward shift and the enhancement of maximum responses to NE by cocaine (2.9 X 10(-4) M), and (iii) reduced only the maximum responses to KCl. In denervated preparations, 1.35 X 10 (-3) M Li+ shifted the concentration response curve of NE to the left without any change in the maximum responses. The antagonistic effects of Li+ on maximal responses to NE, ACh and KCl observed in innervated preparations were significantly increased in Ca++-free medium. Li+ (1.35 X 10(-3) M) increased NE uptake by the seminal vesicle significantly. It is concluded that decreased sensitivity of the seminal vesicle to NE by Li+ could be due to an increase in the uptake of NE and to a nonspecific postsynaptic spasmolytic action.

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Year:  1979        PMID: 218237     DOI: 10.1159/000137232

Source DB:  PubMed          Journal:  Pharmacology        ISSN: 0031-7012            Impact factor:   2.547


  3 in total

1.  Peripheral noradrenergic function during chronic lithium treatment in the rat.

Authors:  J P Finberg; I Kremer; I Spanir; R H Lenox; E Klein
Journal:  J Neural Transm Gen Sect       Date:  1992

2.  Effect of ageing on the number of neuronal noradrenaline uptake sites in the rat vas deferens.

Authors:  R P Markus; M C Werneck de Avellar
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-10       Impact factor: 3.000

3.  Relaxant effects of lithium on guinea-pig tracheal smooth muscle in vitro.

Authors:  S R Sampson; C Weiss-Rotem
Journal:  Br J Pharmacol       Date:  1982-02       Impact factor: 8.739

  3 in total

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