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Literature DB >> 21822688

Strain-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning.

George S Portugal¹, Derek S Wilkinson, Justin W Kenney, Colleen Sullivan, Thomas J Gould.

Abstract

The effects of nicotine on cognitive processes such as learning and memory may play an important role in the addictive liability of tobacco. However, it remains unknown whether genetic variability modulates the effects of nicotine on learning and memory. The present study characterized the effects of acute, chronic, and withdrawal from chronic nicotine administration on fear conditioning, somatic signs, and the elevated plus maze in 8 strains of inbred mice. Strain-dependent effects of acute nicotine and nicotine withdrawal on contextual fear conditioning, somatic signs, and the elevated plus maze were observed, but no association between the effects of acute nicotine and nicotine withdrawal on contextual fear conditioning were observed, suggesting that different genetic substrates may mediate these effects. The identification of genetic factors that may alter the effects of nicotine on cognition may lead to more efficacious treatments for nicotine addiction.

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Year: 2011 PMID： 21822688 PMCID： PMC3788685 DOI： 10.1007/s10519-011-9489-7

Source DB: PubMed Journal: Behav Genet ISSN： 0001-8244 Impact factor: 2.805

65 in total

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4. Genetic relationship between ethanol-induced conditioned place preference and other ethanol phenotypes in 15 inbred mouse strains.

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10. Genetic background influences the effects of withdrawal from chronic nicotine on learning and high-affinity nicotinic acetylcholine receptor binding in the dorsal and ventral hippocampus.

Authors: Derek S Wilkinson; Jill R Turner; Julie A Blendy; Thomas J Gould
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