| Literature DB >> 21821281 |
Min Soo Bae1, Dae Hyeok Yang, Jung Bok Lee, Dong Nyoung Heo, Yong-Dae Kwon, In Chan Youn, Kuiwon Choi, Jong Hyun Hong, Gye Tae Kim, Yong Suk Choi, Eui Hwan Hwang, Il Keun Kwon.
Abstract
We describe in this study the positive influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with simvastatin (SIM). Prior to loading SIM, we first characterized the HA hydrogels for their mechanical properties and swelling ratios. The results from this testing indicated that these two factors improved as the substitution degree of 2-aminoethyl methacrylate (AEMA) increased. MTT and live/dead assays showed that the HA hydrogels have good biocompatibility for use as scaffolds for bone tissue regeneration. Moreover, another MTT assay showed that the photo-cured HA hydrogels III fabricated with 30% AEMA (300 mg) conjugated HA (HA-AEMA iii) loaded with between 0.1 and 1 mg of SIM had a similar cytotoxicity as compared to the HA hydrogel III itself. The sustained release of SIM was observed to occur in the HA hydrogel III loaded with 1 mg of SIM. In vitro and in vivo experiments showed that the HA hydrogel III loaded with 1 mg of SIM had a significant influence on osteogenesis.Entities:
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Year: 2011 PMID： 21821281 DOI： 10.1016/j.biomaterials.2011.07.045
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479