Literature DB >> 21820627

Cell migration: PKA and RhoA set the pace.

Karen A Newell-Litwa1, Alan Rick Horwitz.   

Abstract

A new study shows that protein kinase A (PKA) activity establishes a signaling loop that governs protrusion-retraction cycles in migrating cells. PKA activity near the leading edge of protrusions phosphorylates RhoA and inhibits its activity via increased association with RhoGDI.
Copyright © 2011 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21820627     DOI： 10.1016/j.cub.2011.06.032

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  8 in total

1.  PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration.

Authors:  Chandrima Sinha; Aixia Ren; Kavisha Arora; Chang Suk Moon; Sunitha Yarlagadda; Koryse Woodrooffe; Songbai Lin; John D Schuetz; Assem G Ziady; Anjaparavanda P Naren
Journal:  Cell Signal       Date:  2015-04-02       Impact factor: 4.315

2.  An RNA-binding protein, RNP-1, protects microtubules from nocodazole and localizes to the leading edge during cytokinesis and cell migration in Dictyostelium cells.

Authors:  Thu Ngo; Xin Miao; Douglas N Robinson; Qiong-Qiong Zhou
Journal:  Acta Pharmacol Sin       Date:  2016-08-29       Impact factor: 6.150

3.  Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes.

Authors:  Lisa Buvall; Hanna Wallentin; Jonas Sieber; Svetlana Andreeva; Hoon Young Choi; Peter Mundel; Anna Greka
Journal:  J Am Soc Nephrol       Date:  2016-09-14       Impact factor: 10.121

4.  Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase.

Authors:  Colin P O'Banion; Melanie A Priestman; Robert M Hughes; Laura E Herring; Stephen J Capuzzi; David S Lawrence
Journal:  Cell Chem Biol       Date:  2017-11-05       Impact factor: 8.116

5.  PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.

Authors:  Frankie Chi Fat Ko; Lo-Kong Chan; Karen Man-Fong Sze; Yin-Shan Yeung; Edith Yuk-Ting Tse; Ping Lu; Ming-Hua Yu; Irene Oi-Lin Ng; Judy Wai Ping Yam
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

6.  Motility efficiency and spatiotemporal synchronization in non-metastatic vs. metastatic breast cancer cells.

Authors:  Thomas M Hermans; Didzis Pilans; Sabil Huda; Patrick Fuller; Kristiana Kandere-Grzybowska; Bartosz A Grzybowski
Journal:  Integr Biol (Camb)       Date:  2013-12       Impact factor: 2.192

7.  Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.

Authors:  Wei-Chien Hung; Jessica R Yang; Christopher L Yankaskas; Bin Sheng Wong; Pei-Hsun Wu; Carlos Pardo-Pastor; Selma A Serra; Meng-Jung Chiang; Zhizhan Gu; Denis Wirtz; Miguel A Valverde; Joy T Yang; Jin Zhang; Konstantinos Konstantopoulos
Journal:  Cell Rep       Date:  2016-05-05       Impact factor: 9.423

8.  FRET biosensor allows spatio-temporal observation of shear stress-induced polar RhoGDIα activation.

Authors:  Shuai Shao; Xiaoling Liao; Fei Xie; Sha Deng; Xue Liu; Tapani Ristaniemi; Bo Liu
Journal:  Commun Biol       Date:  2018-12-10
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.