OBJECTIVE: To evaluate the effectiveness of screening using visual inspection with acetic acid (VIA). METHODS: In a low-resource area of Peru in 2005-2008, a randomly selected sample of women who had previously screened negative by VIA and Pap (intervention group), and a group of eligible women previously unscreened by VIA (comparison group) were screened by VIA. The outcome measures were histologically confirmed cervical intraepithelial neoplasia (CIN) 2-3 and invasive cervical cancer. RESULTS: There were 4252 women in the intervention group and 4392 in the comparison group. Histologically confirmed CIN 2 or worse was diagnosed in 31 (0.7%) and 115 (2.6%) women, and invasive cancer was diagnosed in 4 women (0.09%) and 43 women (1.00%), in the intervention and comparison groups, respectively. The adjusted odds ratio was 4.2 (95% confidence interval [CI], 2.7-6.4) for CIN 2 or worse, and 13.9 (95% CI, 4.9-39.6) for invasive cervical cancer in the comparison group. CONCLUSION: A lower prevalence of CIN 2-3 and invasive cervical cancer was seen in women previously screened by VIA, as compared with women not previously screened by VIA, implying that a single VIA screening can lower the population risk for cervical cancer.
OBJECTIVE: To evaluate the effectiveness of screening using visual inspection with acetic acid (VIA). METHODS: In a low-resource area of Peru in 2005-2008, a randomly selected sample of women who had previously screened negative by VIA and Pap (intervention group), and a group of eligible women previously unscreened by VIA (comparison group) were screened by VIA. The outcome measures were histologically confirmed cervical intraepithelial neoplasia (CIN) 2-3 and invasive cervical cancer. RESULTS: There were 4252 women in the intervention group and 4392 in the comparison group. Histologically confirmed CIN 2 or worse was diagnosed in 31 (0.7%) and 115 (2.6%) women, and invasive cancer was diagnosed in 4 women (0.09%) and 43 women (1.00%), in the intervention and comparison groups, respectively. The adjusted odds ratio was 4.2 (95% confidence interval [CI], 2.7-6.4) for CIN 2 or worse, and 13.9 (95% CI, 4.9-39.6) for invasive cervical cancer in the comparison group. CONCLUSION: A lower prevalence of CIN 2-3 and invasive cervical cancer was seen in women previously screened by VIA, as compared with women not previously screened by VIA, implying that a single VIA screening can lower the population risk for cervical cancer.
Authors: Andrea Thoumi; Sarah J Bond; Mary Elizabeth Dotson; Marlee Krieger; Patricia J Garcia; Nirmala Ramanujam Journal: Ann Glob Health Date: 2021-11-24 Impact factor: 2.462
Authors: Geneva A DeGregorio; Leslie S Bradford; Simon Manga; Pius M Tih; Richard Wamai; Rebecca Ogembo; Zacharie Sando; Yuxin Liu; Constance Schwaiger; Sowmya R Rao; Karen Kalmakis; Lisa Kennedy Sheldon; Kathleen Nulah; Edith Welty; Thomas Welty; Javier Gordon Ogembo Journal: PLoS One Date: 2016-06-09 Impact factor: 3.240
Authors: José Revilla-López; Andrea Anampa-Guzmán; Luis Casanova Marquez; Katrina Weeks; Suzanne Pollard; Adriel Olórtegui-Yzú; María Ruiz-Velazco; Alba Davila-Edquen; Daniel Castro-Dorer; Juan Wong-Barrenechea; Jossira Abad-Seminario; Pamela Gonzáles-Ramos; Fiorella Rivera-Sandoval; Carlos Carracedo-Gonzáles Journal: Infect Agent Cancer Date: 2019-11-29 Impact factor: 2.965